Oral Health and Society Unit, Faculty of Dentistry, McGill University, Montreal, QC, Canada; Epidemiology Unit, INRS-Institut Armand-Frappier, Laval, QC, Canada.
J Clin Periodontol. 2013 Nov;40(11):986-93. doi: 10.1111/jcpe.12146. Epub 2013 Aug 26.
To investigate whether metabolic syndrome (MetS) and its components are associated with gingival inflammation in children.
This is a cross-sectional analysis from the baseline visit of the QUebec Adipose and Lifestyle InvesTigation in Youth cohort, an ongoing longitudinal study investigating the natural history of obesity in children of Quebec, Canada. The analytic sample includes 448 children aged 8-10 years, 39% of whom were overweight or obese. MetS was defined according to the International Diabetes Federation recommendations. Gingival inflammation was defined by the level of gingival crevicular fluid (GCF) tumour necrosis factor alpha (TNF-α) and the extent of gingival bleeding. Sex-specific linear regression analyses estimated the associations between MetS and gingival inflammation, adjusting for potential confounders.
Twenty-five children had MetS. Boys with MetS compared to those without, had a 49.5% (p-value = 0.001) higher GCF TNF-α level and 13.7% (p-value = 0.033) more sites with gingival bleeding. Moreover, for three of the five components of MetS - waist circumference, fasting plasma triglycerides, systolic blood pressure - an increase was associated with increased GCF TNF-α level in boys. No such findings were seen in girls.
An association between MetS and gingival inflammation was observed as early as in childhood, and may differ by sex.
探讨代谢综合征（MetS）及其组分是否与儿童牙龈炎症相关。
这是来自加拿大魁北克青少年脂肪与生活方式纵向研究的基线调查的横断面分析，该研究正在调查肥胖儿童的自然史。分析样本包括 448 名 8-10 岁的儿童，其中 39%超重或肥胖。MetS 根据国际糖尿病联合会的建议定义。牙龈炎症通过龈沟液（GCF）肿瘤坏死因子-α（TNF-α）水平和牙龈出血程度来定义。性别特异性线性回归分析调整了潜在混杂因素后，估计了 MetS 与牙龈炎症之间的关联。
25 名儿童患有 MetS。与没有 MetS 的男孩相比，患有 MetS 的男孩 GCF TNF-α水平高 49.5%（p 值=0.001），牙龈出血的位点多 13.7%（p 值=0.033）。此外，对于 MetS 的五个组成部分中的三个 - 腰围、空腹血浆甘油三酯、收缩压 - 在男孩中，随着水平的增加，GCF TNF-α水平也随之增加。在女孩中没有发现这种情况。
早在儿童时期就观察到 MetS 与牙龈炎症之间存在关联，并且可能因性别而异。
