Department of Internal Medicine, Federal Teaching Hospital Abakaliki, State of Ebonyi, Nigeria.
Rev Soc Bras Med Trop. 2013 Jul-Aug;46(4):525-7. doi: 10.1590/0037-8682-0098-2013.
Artemisinin-based combination therapy-resistant malaria is rare in Sub-Saharan Africa. The World Health Organization identifies monitoring and surveillance using day-3 parasitaemia post-treatment as the standard test for identifying suspected artemisinin resistance. We report three cases of early treatment failure due to possible artemisinin-based combination therapy-resistant Plasmodium falciparum malaria. All cases showed adequate clinical and parasitological responses to quinine. This study reveals a need to re-evaluate the quality and efficacy of artemisinin-based combination therapy agents in Nigeria and Sub-Saharan Africa.
青蒿素类复方疗法耐药性疟疾在撒哈拉以南非洲很少见。世界卫生组织确定，使用治疗后第 3 天的疟原虫血症进行监测和监测是识别疑似青蒿素耐药性的标准检测方法。我们报告了三例因可能的青蒿素类复方疗法耐药性恶性疟原虫疟疾而导致的早期治疗失败的病例。所有病例对奎宁均显示出充分的临床和寄生虫学反应。本研究表明，需要重新评估尼日利亚和撒哈拉以南非洲青蒿素类复方疗法药物的质量和疗效。
