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评估髋膝关节疾病患者生活质量测量的表现及其对研究和临床应用的影响。

Performance of the assessment of quality of life measure in people with hip and knee joint disease and implications for research and clinical use.

机构信息

Melbourne EpiCentre, Royal Melbourne Hospital, and The University of Melbourne, Parkville, Victoria, Australia.

出版信息

Arthritis Care Res (Hoboken). 2014 Mar;66(3):481-8. doi: 10.1002/acr.22129.

Abstract

OBJECTIVE

To comprehensively evaluate the performance of the Assessment of Quality of Life (AQoL) instrument for measuring health-related quality of life (HRQOL) in people with hip and knee joint disease (arthritis or osteoarthritis).

METHODS

Data from 237 individuals were available for analysis from a national cross-sectional, population-based study of hip and knee joint disease in Australia. AQoL-4D data were evaluated using Rasch analysis. A range of measurement properties was explored, including model and item fit, threshold ordering, differential item functioning, and targeting.

RESULTS

Good overall fit of the AQoL with the Rasch model was demonstrated across a range of tests, supporting internal validity. Only 1 item (relating to hearing) showed evidence of misfit. Most AQoL items showed logical sequencing of response option categories, with threshold disordering evident for only 2 of the 12 items (items 4 and 9). Minor issues with potential clinical and research implications include limited options for reporting pain and some evidence of measurement bias between demographic subgroups (including age and sex). Participants' HRQOL was generally better than that represented by the AQoL items (mean ± SD for person abilities -2.15 ± 1.39, mean ± SD for item difficulties 0.00 ± 0.67), indicating ceiling effects that could impact the instrument's ability to detect HRQOL improvement in population-based studies.

CONCLUSION

The AQoL is a competent tool for assessing HRQOL in people with hip and knee joint disease, although researchers and clinicians should consider the caveats identified when selecting appropriate HRQOL measures for future outcome assessment involving this patient group.

摘要

目的

全面评估用于测量髋膝关节疾病(关节炎或骨关节炎)患者健康相关生活质量(HRQOL)的生活质量评估(AQoL)工具的性能。

方法

澳大利亚一项全国性横断面、基于人群的髋膝关节疾病研究中,有 237 名个体的数据可用于分析。使用 Rasch 分析评估 AQoL-4D 数据。探讨了一系列测量特性,包括模型和项目拟合、阈值排序、差异项目功能和目标。

结果

在一系列测试中,AQoL 与 Rasch 模型的总体拟合良好,支持内部有效性。只有 1 项(与听力有关)显示拟合不良的证据。大多数 AQoL 项目显示出反应选项类别的逻辑排序,只有 12 项中的 2 项(第 4 项和第 9 项)存在阈值紊乱。潜在的临床和研究意义上的一些小问题包括报告疼痛的选项有限,以及在人口统计学亚组(包括年龄和性别)之间存在测量偏差的证据。参与者的 HRQOL 通常优于 AQoL 项目所代表的(个体能力的平均值 ± 标准差-2.15 ± 1.39,项目难度的平均值 ± 标准差 0.00 ± 0.67),表明存在天花板效应,这可能会影响该工具在基于人群的研究中检测 HRQOL 改善的能力。

结论

AQoL 是评估髋膝关节疾病患者 HRQOL 的一种有能力的工具,但研究人员和临床医生在选择适合未来涉及该患者群体的结果评估的 HRQOL 测量方法时,应考虑到确定的注意事项。

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