Hudlicka O, Torres S H
Department of Physiology, University of Birmingham, England.
J Med. 1990;21(3-4):165-80.
Vascular casts were prepared using Batson Anatomical corrosion compound, from maximally dilated rat tibialis anterior (TA), extensor digitorum longus (EDL) and soleus (SOL) with normal and limited blood supply (unilateral ligation of the common iliac artery). The weight of casts was expressed as a percentage of muscle wet weight. This value was considered representative for the size of the vascular bed. The value was 2.9 +/- 0.12% (mean +/- SEM) in normal TA, 3.37 +/- 0.15% in EDL and 4.8 +/- 0.43% in SOL. The weight of vascular casts decreased in all muscles to 40% of the values found in the contralateral muscles one week after ligation. Five weeks after ligation, it was about 60% of the control values in TA and EDL, and 80% in SOL. Treatment with torbafylline for one week did not change the weight of the vascular casts. After five weeks the size of the vascular bed was back to control values in EDL and SOL, and only 20% lower than control muscles in TA. This could be attributed to improved development of collateral circulation. Treatment with pentoxifylline improved collateral circulation only in SOL.
使用巴特森解剖学腐蚀复合物制备血管铸型，取材于最大扩张状态下的大鼠胫前肌（TA）、趾长伸肌（EDL）和比目鱼肌（SOL），这些肌肉分别具有正常和有限的血液供应（单侧结扎髂总动脉）。铸型重量以肌肉湿重的百分比表示。该值被认为代表血管床的大小。正常TA的该值为2.9±0.12%（平均值±标准误），EDL为3.37±0.15%，SOL为4.8±0.43%。结扎一周后，所有肌肉中血管铸型的重量均降至对侧肌肉中所测值的40%。结扎五周后，TA和EDL中约为对照值的60%，SOL中为80%。用托巴茶碱治疗一周并未改变血管铸型的重量。五周后，EDL和SOL中血管床大小恢复至对照值，TA中仅比对照肌肉低20%。这可归因于侧支循环的改善。己酮可可碱治疗仅改善了SOL中的侧支循环。
