Tong Yanqing, Leng Yan, Bai Jingli
The First Affilliated Hospital to Changchun University of Chinese Medicine, Department of Nephrology, Changchun City, Jilin Province, China.
Afr J Tradit Complement Altern Med. 2011 Dec 29;9(2):266-70. doi: 10.4314/ajtcam.v9i2.13. eCollection 2012.
We have used reduced doses of Chinese herbs for estimation of urinary tract infections (UTIs) patients with stable impairment of renal function. A total of 33 adult female patients with moderately impaired renal function and symptomatic UTIs were included in this study. Urine cultures were carried out. Patients were monitored clinically and with various laboratory tests. Chinese herbal concoction divided by milligrams of creatinine per 100 ml were orally administrated for ten days. Three patients were excluded from final analysis. Most of the patients responded symptomatically to treatment. Chinese herbs eradicated the primary pathogen in 68.7% of the patients at the day 10 of treatment. Two patients relapsed (one had abbreviated courses of therapy) 6 to 8 days posttreatment. Organisms which recurred included Escherichia coli and Pseudomonas aeruginosa. Bacterial reinfections occurred 5 to 8 days posttreatment in four patients. Adverse reactions observed among the 30 patients were rare. Nausea (6.67%) and mild elevation of hepatic enzymes (3.33%) were probably drug related. Nausea disappeared when the therapy ended. Elevated hepatic enzymes resumed at the 2-week follow-up. Two patients demonstrated slight increases in serum creatinine on day 10 of treatment. One patient had a 12.5% elevation over baseline and the other had a 13.0% elevation. Serum creatinine values had improved in these two patients at 4-week follow-up. Chinese herbal medicine was effective and safe in the treatment of UTIs with renal insufficiency.
我们使用了减量的中药来评估肾功能稳定受损的尿路感染（UTIs）患者。本研究共纳入33例肾功能中度受损且有症状性UTIs的成年女性患者。进行了尿培养。对患者进行了临床监测和各种实验室检查。按每100 ml肌酐毫克数计算的中药合剂口服给药10天。3例患者被排除在最终分析之外。大多数患者对治疗有症状反应。在治疗第10天时，中药在68.7%的患者中根除了主要病原体。2例患者在治疗后6至8天复发（1例疗程缩短）。复发的病原体包括大肠杆菌和铜绿假单胞菌。4例患者在治疗后5至8天发生细菌再感染。在30例患者中观察到的不良反应很少。恶心（6.67%）和肝酶轻度升高（3.33%）可能与药物有关。治疗结束时恶心消失。肝酶升高在2周随访时恢复。2例患者在治疗第10天时血清肌酐略有升高。1例患者比基线升高12.5%，另1例升高13.0%。在4周随访时，这2例患者的血清肌酐值有所改善。中药治疗肾功能不全的UTIs有效且安全。
