Tong Yanqing, Jing Yue, Zhao Dongkai, Zhang Liping, Zeng Shiming
Department of Nephrology, The First Affilliated Hospital to Changchun University of Chinese Medicine, Changchun city, Jilin province, China.
Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):108-14. doi: 10.4314/ajtcam.v8i5S.18. Epub 2011 Jul 3.
We assessed the effects of Chinese herbs on the uncomplicated urinary tract infections (UTIs) in women caused by fluoroquinolone-resistant strains. A total of 56 pre-menopausal women with uncomplicated UTIs caused by fluoroquinolone-resistant strains were included. Urine cultures were carried out. All organisms were proved to be fluoroquinolone-resistant at baseline. The patients were orally administrated Chinese herbal concoction for ten days. Chinese herbal concoction eradicated the primary pathogen in 71.4% of the patients at the 1-week follow-up. Among the 20 patients who had bacteriologic failures in the Day 5 of treatment, 2 developed superinfection. Of the failures in the group, Proteus mirabilis, Staphylococcus epidermidis and Providencia rettgeri were implicated in 50.0%, 50.0% and 100.0% of the failures, respectively. The clinical outcomes were also good, with cure or improvement for more than 80% of all subjects. About 14% of the study subjects reported at least one potential adverse event. The adverse events most frequently reported were nausea and diarrhea. All patients tolerated the symptoms. The adverse reactions did not prevail after discontinuation of the medication. Chinese herbal therapy may be an acceptable alternative for the treatment of uncomplicated UTIs caused by fluoroquinolone-resistant uropathogens.
我们评估了中药对由耐氟喹诺酮菌株引起的女性单纯性尿路感染（UTIs）的疗效。共纳入56例由耐氟喹诺酮菌株引起单纯性UTIs的绝经前女性。进行了尿培养。所有微生物在基线时均被证明对氟喹诺酮耐药。患者口服中药煎剂10天。在1周随访时，中药煎剂使71.4%的患者根除了主要病原体。在治疗第5天细菌学治疗失败的20例患者中，2例发生了二重感染。在该组治疗失败的病例中，奇异变形杆菌、表皮葡萄球菌和雷氏普罗威登斯菌分别占失败病例的50.0%、50.0%和100.0%。临床结局也较好，超过80%的受试者治愈或病情改善。约14%的研究受试者报告至少发生过一次潜在不良事件。最常报告的不良事件是恶心和腹泻。所有患者均耐受这些症状。停药后不良反应未持续存在。中药疗法可能是治疗由耐氟喹诺酮尿路病原体引起的单纯性UTIs的一种可接受的替代方法。
