暴露于香烟烟雾的大鼠雄性附属生殖器官的组织学变化及蜂蜜补充的保护作用。
Histological changes in male accessory reproductive organs in rats exposed to cigarette smoke and the protective effect of honey supplementation.
作者信息
Mohamed Mahaneem, Sulaiman Siti Amrah, Jaafar Hasnan
机构信息
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
出版信息
Afr J Tradit Complement Altern Med. 2012 Apr 2;9(3):329-35. doi: 10.4314/ajtcam.v9i3.5. eCollection 2012.
The effect of cigarette smoke (CS) on histology of male accessory reproductive organs and the possible protective effect of honey supplementation in rats were investigated in this study. Rats received distilled water, honey, CS exposure or honey plus CS exposure. Honey (1.2 g/kg body weight/day) was administered by gavage and CS exposure (3 times per day) was done in a chamber for 13 weeks. CS exposure significantly increased relative weight of epididymis and ventral prostate. There were also significantly increased number of clear cells and epithelial height of cauda epididymis as well as severe interstitial oedema and decreased epithelial height of prostate gland. However, with the supplementation of honey, these histological changes were significantly reversed suggesting the protective effect of honey against the toxic effect of CS on male accessory reproductive organs in rats.
本研究调查了香烟烟雾（CS）对雄性大鼠附属生殖器官组织学的影响以及补充蜂蜜可能产生的保护作用。将大鼠分为四组，分别给予蒸馏水、蜂蜜、暴露于香烟烟雾或同时给予蜂蜜并暴露于香烟烟雾。通过灌胃给予蜂蜜（1.2克/千克体重/天），并将大鼠置于烟雾暴露舱中每天暴露3次，持续13周。暴露于香烟烟雾显著增加了附睾和腹侧前列腺的相对重量。附睾尾部的透明细胞数量和上皮高度也显著增加，同时前列腺出现严重的间质水肿且上皮高度降低。然而，补充蜂蜜后，这些组织学变化得到显著逆转，表明蜂蜜对香烟烟雾对大鼠雄性附属生殖器官的毒性作用具有保护作用。
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