Beya Wabeya, Davidson Bruce, Erlwanger Kennedy H
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown 2193, South Africa.
Afr J Tradit Complement Altern Med. 2012 Jul 1;9(4):553-60. eCollection 2012.
The gastrointestinal tract of neonates is sensitive to dietary manipulations. When nursing mothers use Aloe vera, their babies are at risk of indirect exposure to Aloe vera via breast feeding or directly as health supplements. The effects of orally administered extracts of Aloe vera in unweaned rats were investigated. Six day old Sprague-Dawley rats were gavaged with aqueous or alcohol extracts of Aloe vera (low dose 50mg. kg⁻¹ or high dose 500mg. kg⁻¹) daily for eight days. All data were expressed as mean ± SD and analyzed by one way ANOVA. Pups receiving high doses of either extract had a significantly higher body mass gain than the group receiving lower dose (p < 0.05). Tibial length was significantly increased in the high dose aqueous extract group (15-26%). The differences in growth could not be attributed to circulating insulin-like growth factor-1 as the levels were not significantly different. The caecum was significantly enlarged in the rats that received the high doses of both extracts. Although, there was no significant difference in the non-fasting plasma concentration of glucose and triglycerides, the hepatic lipid and glycogen content were significantly higher (p < 0.001) for the high dose aqueous extract group. The plasma alanine transaminase was not affected by the treatments, however the high doses of the extracts significantly increased plasma alkaline phosphatase activity. Short term administration of Aloe vera extracts resulted in growth promotion, enhanced hepatic storage of metabolic substrates, increased ALP possibly in relation to bone growth and caused hypertrophy of the caecum of neonatal rats. These effects need to be explored further to enhance animal production and health.
新生儿的胃肠道对饮食调整很敏感。当哺乳期母亲使用芦荟时，她们的婴儿有通过母乳喂养间接接触芦荟或直接作为健康补充剂接触芦荟的风险。研究了口服芦荟提取物对未断奶大鼠的影响。对6日龄的斯普拉格-道利大鼠每天灌胃给予芦荟水提取物或醇提取物（低剂量50mg·kg⁻¹或高剂量500mg·kg⁻¹），持续8天。所有数据均以平均值±标准差表示，并通过单因素方差分析进行分析。接受高剂量任一提取物的幼崽体重增加显著高于接受低剂量的组（p<0.05）。高剂量水提取物组的胫骨长度显著增加（15 - 26%）。生长差异不能归因于循环胰岛素样生长因子-1，因为其水平无显著差异。接受高剂量两种提取物的大鼠盲肠显著增大。虽然，空腹血糖和甘油三酯的血浆浓度无显著差异，但高剂量水提取物组的肝脏脂质和糖原含量显著更高（p<0.001）。血浆丙氨酸转氨酶不受处理影响，然而高剂量提取物显著增加了血浆碱性磷酸酶活性。短期给予芦荟提取物导致生长促进、肝脏代谢底物储存增加、碱性磷酸酶可能与骨骼生长相关增加，并导致新生大鼠盲肠肥大。这些影响需要进一步探索以提高动物生产和健康水平。
