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肉芽肿性多血管炎中的硬脑膜炎：一例报告并文献复习

Pachymeningitis in granulomatosis with polyangiitis: a case report and a review of the literature.

作者信息

Sakellariou Grigorios T, Kefala Nicoleta

机构信息

Department of Rheumatology, 424 General Military Hospital, 564 03 Thessaloniki, Greece.

出版信息

Case Rep Rheumatol. 2013;2013:840984. doi: 10.1155/2013/840984. Epub 2013 Aug 6.

DOI:10.1155/2013/840984
PMID:23984161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3748409/
Abstract

Central nervous involvement, mainly with symptoms of cranial neuropathies, occurs in 2-8% of patients with granulomatosis with polyangiitis (GPA). Meningeal involvement, with persistent and severe headache as main manifestation and abnormal thickening and enhancement of the dural mater on postcontrast magnetic resonance imaging, is extremely rare. We present a case of pachymeningitis due to limited GPA, providing simultaneously a literature review.

摘要

中枢神经系统受累主要表现为颅神经病变症状，在显微镜下多血管炎（GPA）患者中发生率为2% - 8%。脑膜受累以持续性严重头痛为主要表现，在增强磁共振成像上表现为硬脑膜异常增厚和强化，极为罕见。我们报告一例局限性GPA所致的硬脑膜炎病例，并同时进行文献复习。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/914716612fd7/CRIM.RHEUMATOLOGY2013-840984.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/618bef6680c2/CRIM.RHEUMATOLOGY2013-840984.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/5f615ca2e5f7/CRIM.RHEUMATOLOGY2013-840984.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/914716612fd7/CRIM.RHEUMATOLOGY2013-840984.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/618bef6680c2/CRIM.RHEUMATOLOGY2013-840984.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/5f615ca2e5f7/CRIM.RHEUMATOLOGY2013-840984.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d021/3748409/914716612fd7/CRIM.RHEUMATOLOGY2013-840984.003.jpg

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2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.2012年修订的国际 Chapel Hill 共识会议血管炎命名法
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Refractory Wegener's meningitis treated with rituximab.用利妥昔单抗治疗难治性韦格纳脑膜炎。
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Meningeal involvement in Wegener's granulomatosis is associated with localized disease.韦格纳肉芽肿病的脑膜受累与局限性疾病相关。
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Successful treatment of meningeal involvement in Wegener's granulomatosis with infliximab.英夫利昔单抗成功治疗韦格纳肉芽肿病的脑膜受累情况。
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