Murphy J M, Gomez-Anson B, Gillard J H, Antoun N M, Cross J, Elliott J D, Lockwood M
Department of Radiology, Addenbrooke's Hospital, England.
Radiology. 1999 Dec;213(3):794-9. doi: 10.1148/radiology.213.3.r99dc11794.
To determine the spectrum of intracranial magnetic resonance (MR) imaging appearances of Wegener granulomatosis.
MR imaging studies in 19 patients with Wegener granulomatosis and possible central nervous system involvement were reviewed by two neuroradiologists. Intermediate-weighted and T2-weighted fast spin-echo MR images of the brain had been acquired in all patients, and spin-echo T1-weighted nonenhanced and gadolinium-enhanced images had been acquired in 18 patients.
MR imaging findings included diffuse linear dural thickening and enhancement (n = 6); focal dural thickening and enhancement contiguous with orbital, nasal, or paranasal disease (n = 5); infarcts (n = 4); nonspecific white matter areas of high signal intensity on intermediate-weighted and T2-weighted images (n = 10); enlarged pituitary gland with infundibular thickening and enhancement (n = 2); a discrete cerebellar lesion that was probably granulomatous in origin (n = 1); and cerebral (n = 8) and cerebellar atrophy (n = 2).
MR imaging demonstrated the wide spectrum of findings of central nervous system involvement in patients with Wegener granulomatosis and was particularly useful for the evaluation of direct intracranial spread from orbital, nasal, or paranasal disease.
确定韦格纳肉芽肿病的颅内磁共振成像表现谱。
两名神经放射科医生回顾了19例可能累及中枢神经系统的韦格纳肉芽肿病患者的磁共振成像研究。所有患者均获取了脑部的中等加权和T2加权快速自旋回波磁共振图像，18例患者获取了自旋回波T1加权非增强和钆增强图像。
磁共振成像表现包括弥漫性硬脑膜增厚及强化（n = 6）；与眼眶、鼻腔或鼻窦疾病相邻的局灶性硬脑膜增厚及强化（n = 5）；梗死灶（n = 4）；中等加权和T2加权图像上非特异性高信号强度的白质区域（n = 10）；垂体增大伴漏斗部增厚及强化（n = 2）；一个可能起源于肉芽肿的离散小脑病变（n = 1）；以及脑萎缩（n = 8）和小脑萎缩（n = 2）。
磁共振成像显示了韦格纳肉芽肿病患者中枢神经系统受累的广泛表现谱，对评估眼眶、鼻腔或鼻窦疾病向颅内的直接蔓延特别有用。
