Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan.
Biomed Res Int. 2013;2013:108794. doi: 10.1155/2013/108794. Epub 2013 Jul 31.
An anthropomorphic phantom was used to investigate a treatment technique and analyze the dose distributions for helical irradiation of the total skin (HITS) by helical tomotherapy (HT). Hypothetical bolus of thicknesses of 0, 10, and 15 mm was added around the phantom body to account for the dose homogeneity and setup uncertainty. A central core structure was assigned as a "complete block" to force the dose tangential delivery. HITS technique with prescribed dose (D p ) of 36 Gy in 36 fractions was generated. The radiochromic EBT2 films were used for the dose measurements. The target region with 95.0% of the D p received by more than 95% of the PTV was obtained. The calculated mean doses for the organs at risk (OARs) were 4.69, 3.10, 3.20, and 2.94 Gy for the lung, heart, liver, and kidneys, respectively. The measurement doses on a phantom surface for a plan with 10 mm hypothetical bolus and bolus thicknesses of 0, 1, 2, and 3 mm are 89.5%, 111.4%, 116.9%, and 117.7% of D p , respectively. HITS can provide an accurate and uniform treatment dose in the skin with limited doses to OARs and is safe to replace a total skin electron beam regimen.
使用拟人化体模研究了螺旋断层放疗(HT)的全皮肤螺旋照射(HITS)治疗技术,并分析了剂量分布。在体模周围添加了厚度为 0、10 和 15 毫米的假设模体,以考虑剂量均匀性和设置不确定性。中央核心结构被指定为“完整块”,以强制剂量切线递送。生成了规定剂量(D p)为 36 Gy 的 36 个分数的 HITS 技术。使用光致变色 EBT2 胶片进行剂量测量。获得了靶区 95.0%的 D p 由 PTV 的 95%以上接收的结果。对于肺、心脏、肝脏和肾脏等危及器官(OARs),计算得到的平均剂量分别为 4.69、3.10、3.20 和 2.94 Gy。对于计划中带有 10 毫米假设模体和 0、1、2 和 3 毫米的模体厚度,在体模表面上测量的剂量分别为 D p的 89.5%、111.4%、116.9%和 117.7%。HITS 可以为皮肤提供准确且均匀的治疗剂量,同时限制对 OARs 的剂量,并且安全,可以替代全身皮肤电子束治疗方案。