Department of Medical Bioengineering Fundamentals, Institute of Technology, Casimir the Great University, Karola Chodkiewicza 30, 85-064 Bydgoszcz, Poland.
Biomed Res Int. 2013;2013:689089. doi: 10.1155/2013/689089. Epub 2013 Jul 29.
We present the new fixation method for RHA (resurfacing hip arthroplasty) endoprostheses by means of the biomimetic multispiked connecting scaffold (MSC-Scaffold). Such connecting scaffold can generate new type of RHA endoprostheses, that is stemless and fixed entirely without cement. The preprototypes of this MSC-Scaffold were manufactured with modern additive laser additive technology (SLM). The pilot surgical implantations in animal model (two laboratory swine) of MSC-Scaffold preprototypes have showed after two months neither implant loosening, migration, and nor other early complications. From the results of performed histopathological evaluation of the periscaffold spikes bone tissue and 10-day culture of human osteoblasts (NHOst) we can conclude that (1) the scaffolding effect was obtained and (2) to improve the osseointegration of the scaffold spikes, their material surface should be physicochemically modified (e.g., with hydroxyapatite). Some histopathological findings in the periscaffold domain near the MSC-Scaffold spikes bases (fibrous connective tissue and metallic particles near the MSC-Scaffold spikes bases edges) prompt considering the necessity to optimize the design of the MSC-Scaffold in the regions of its interspike space near the spikes bases edges, to provide more room for new bone formation in this region and for indispensable post-processing (glass pearl blasting) after the SLM manufacturing.
我们提出了一种新的 RHA（表面髋关节置换）内植物固定方法，即通过仿生多刺连接支架（MSC-Scaffold）。这种连接支架可以生成新型的 RHA 内植物，即无柄且完全无水泥固定。该 MSC-Scaffold 的预原型是使用现代增材激光增材技术（SLM）制造的。MSC-Scaffold 预原型在动物模型（两头实验猪）中的初步手术植入后，两个月内既没有出现植入物松动、迁移，也没有其他早期并发症。从对支架周围骨组织的组织病理学评估结果和人成骨细胞（NHOst）的 10 天培养来看，我们可以得出以下结论：（1）获得了支架效应；（2）为了改善支架刺的骨整合，应该对其材料表面进行物理化学改性（例如，用羟基磷灰石处理）。在 MSC-Scaffold 刺基周围的支架周围区域的一些组织病理学发现（MSC-Scaffold 刺基边缘附近的纤维结缔组织和金属颗粒）促使我们考虑有必要优化 MSC-Scaffold 在其刺基边缘附近的刺间空间区域的设计，以在该区域为新骨形成提供更多空间，并在 SLM 制造后进行必要的后处理（玻璃珠喷砂）。
