Shaaban A A, Tribukait B, el-Bedeiwy A F, Ghoneim M A
Urology and Nephrology Centre, Mansoura University, Egypt.
J Urol. 1990 Oct;144(4):884-7. doi: 10.1016/s0022-5347(17)39615-5.
The deoxyribonucleic acid patterns in lymph node metastases in relation to the degree of ploidy and proliferation in the primary bladder tumor were evaluated in 162 patients who underwent cystectomy for muscle invasive bladder carcinoma. The 34 diploid tumors had given rise to lymph node metastases in only 2 cases (6%), whereas 34% of the aneuploid tumors had metastasized. The frequency of lymph node metastases increased with the proportions of S-phase cells. In transitional cell carcinoma all tumors with a proportion of S-phase cells exceeding 20% had metastasized, while tumors with a proportion of S-phase cells between 10 and 20%, and less than 10% had metastases in 50 and 33%, respectively. The degree of ploidy of aneuploid tumors seems to be of importance for the potential to give rise to metastases, since the majority of metastatic tumors were in the triploid-tetraploid and hyperdiploid but not hypertetraploid regions. The degree of ploidy of lymph node metastases was in good agreement with that of the primary tumors.
对162例行根治性膀胱切除术治疗肌层浸润性膀胱癌的患者，评估了淋巴结转移中的脱氧核糖核酸模式与原发性膀胱肿瘤的倍体程度和增殖情况之间的关系。34例二倍体肿瘤仅有2例（6%）发生淋巴结转移，而异倍体肿瘤的转移率为34%。淋巴结转移频率随S期细胞比例增加而升高。在移行细胞癌中，S期细胞比例超过20%的所有肿瘤均发生转移，而S期细胞比例在10%至20%之间以及低于10%的肿瘤转移率分别为50%和33%。异倍体肿瘤的倍体程度似乎对发生转移的可能性很重要，因为大多数转移瘤处于三倍体 - 四倍体和超二倍体区域，但不处于超四倍体区域。淋巴结转移的倍体程度与原发性肿瘤高度一致。
