Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands.
Am J Clin Nutr. 2013 Oct;98(4):917-23. doi: 10.3945/ajcn.113.062935. Epub 2013 Aug 28.
Weight loss due to a negative energy balance is considered to be accompanied by a decrease in physical activity.
The aim of this study was to investigate whether a decrease in physical activity is sustained during weight maintenance.
Subjects were 20 men and 31 women [mean (±SD) age: 42 ± 8 y; BMI (in kg/m(2)): 31.4 ± 2.8]. Weight loss was achieved by an 8-wk very-low-energy diet period, followed by 44 wk of weight maintenance. Physical activity measures were total energy expenditure expressed as a multiple of sleeping metabolic rate (PALSMR) and resting metabolic rate (PALRMR), activity-induced energy expenditure divided by body weight (AEE/kg), and activity counts measured by a triaxial accelerometer. Measurements took place at 0, 8, and 52 wk.
Body mass decreased significantly during the diet period (10.5 ± 3.8%, P < 0.001), and this reduction was sustained after 52 wk (6.0 ± 5.1%, P < 0.001). PALSMR and PALRMR decreased from 1.81 ± 0.23 and 1.70 ± 0.22, respectively, before the diet to 1.69 ± 0.20 and 1.55 ± 0.19 after the diet (P < 0.001) and increased again after weight maintenance to 1.85 ± 0.27 and 1.71 ± 0.23, respectively, compared with 8-wk measurements (P < 0.001). AEE/kg decreased from 0.043 ± 0.015 MJ/kg at baseline to 0.037 ± 0.014 MJ/kg after the diet (P < 0.001) and was higher after 52 wk (0.044 ± 0.17 MJ/kg) compared with after 8 wk (P < 0.001). Activity counts decreased from 1.64 ± 0.37 megacounts/d at baseline to 1.54 ± 0.35 megacounts/d after the diet (P < 0.05) and were higher after 52 wk (1.73 ± 0.49 megacounts/d) compared with 8 wk (P < 0.01).
A weight loss-induced reduction in physical activity returns to baseline values when weight loss is maintained. This trial was registered at clinicaltrials.gov as NCT01015508.
由于能量负平衡导致的体重减轻被认为伴随着体力活动的减少。
本研究旨在探讨在维持体重期间体力活动是否持续减少。
受试者为 20 名男性和 31 名女性[平均（±SD）年龄：42±8y；BMI（kg/m2）：31.4±2.8]。通过 8 周的极低能量饮食期实现体重减轻，然后进行 44 周的体重维持。体力活动测量值为以睡眠代谢率（PALSMR）的倍数表示的总能量消耗和静息代谢率（PALRMR）、除以体重的活动诱导能量消耗（AEE/kg）以及三轴加速度计测量的活动计数。测量在 0、8 和 52 周进行。
在饮食期间体重明显下降（10.5±3.8%，P<0.001），并且在 52 周后仍保持下降（6.0±5.1%，P<0.001）。PALSMR 和 PALRMR 分别从饮食前的 1.81±0.23 和 1.70±0.22 下降到饮食后的 1.69±0.20 和 1.55±0.19（P<0.001），并在体重维持后再次增加到 1.85±0.27 和 1.71±0.23，与 8 周测量值相比（P<0.001）。AEE/kg 从基线时的 0.043±0.015 MJ/kg 下降到饮食后的 0.037±0.014 MJ/kg（P<0.001），并且在 52 周后（0.044±0.17 MJ/kg）高于 8 周后（P<0.001）。活动计数从基线时的 1.64±0.37 兆计数/d 下降到饮食后的 1.54±0.35 兆计数/d（P<0.05），并且在 52 周后（1.73±0.49 兆计数/d）高于 8 周后（P<0.01）。
当体重减轻得以维持时，体重减轻引起的体力活动减少会恢复到基线值。该试验在 clinicaltrials.gov 上注册为 NCT01015508。
