Jensen Peter, Christensen Robin, Zachariae Claus, Geiker Nina Rw, Schaadt Bente K, Stender Steen, Hansen Peter R, Astrup Arne, Skov Lone
Departments of Dermato-Allergology,
Musculoskeletal Statistics Unit, Parker Institute, Department of Rheumatology, Frederiksberg Hospital and.
Am J Clin Nutr. 2016 Aug;104(2):259-65. doi: 10.3945/ajcn.115.125849. Epub 2016 Jun 22.
Weight reduction may reduce the severity of psoriasis, but little is known about the long-term effects.
We aimed to investigate long-term effects of weight reduction in psoriasis.
We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control group or a low-energy diet (LED) group. Here we followed the participants for an additional 48-wk period. In total, 56 patients with psoriasis [mean ± SD body mass index (in kg/m(2)): 34.4 ± 5.3] underwent a 64-wk weight-loss program consisting of an initial 16-wk randomized phase with an LED for 8 wk and 8 wk of normal food intake combined with 2 LED products/d, followed by a 48-wk period of weight maintenance with the latter diet. After the randomization phase, the control group received the same 8 + 8-wk LED intervention, and all patients were then followed for 48 wk while on the weight-loss maintenance diet. The main outcome was the Psoriasis Area and Severity Index (PASI), and secondary outcome was the Dermatology Life Quality Index (DLQI).
For the present study, 56 patients were eligible, 38 agreed to participate, and 32 completed. After the 16-wk LED-only period, the mean weight loss was -15.0 kg (95% CI: -16.6, -13.4 kg), and PASI and DLQI were reduced by -2.3 (95% CI: -3.1, -1.5) and -2.3 (95% CI: -3.2, -1.4), respectively. At week 64, the mean weight loss compared with baseline was -10.1 kg (95% CI: -12.0, -8.1 kg), and PASI and DLQI were maintained at -2.9 (95% CI: -3.9, -1.9) and -1.9 (95% CI: -3.0, -0.9), respectively.
Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis. This trial was registered at clinicaltrials.gov as NCT01137188.
体重减轻可能会减轻银屑病的严重程度，但对其长期影响知之甚少。
我们旨在研究银屑病患者体重减轻的长期影响。
我们之前进行了一项随机试验（n = 60），纳入银屑病患者，将其分为对照组或低能量饮食（LED）组。在此，我们对参与者进行了额外48周的随访。共有56例银屑病患者[平均±标准差体重指数（kg/m²）：34.4 ± 5.3]接受了为期64周的减肥计划，包括初始16周的随机阶段，其中8周采用低能量饮食，8周正常饮食并每天服用2种低能量饮食产品，随后是48周的维持期，采用后一种饮食方式维持体重。随机阶段后，对照组接受相同的8 + 8周低能量饮食干预，然后所有患者在维持减肥饮食的同时接受48周的随访。主要结局是银屑病面积和严重程度指数（PASI），次要结局是皮肤病生活质量指数（DLQI）。
在本研究中，56例患者符合条件，38例同意参与，32例完成研究。仅低能量饮食的16周后，平均体重减轻-15.0 kg（95%CI：-16.6，-13.4 kg），PASI和DLQI分别降低-2.3（95%CI：-3.1，-1.5）和-2.3（95%CI：-3.2，-1.4）。在第64周时，与基线相比平均体重减轻-10.1 kg（95%CI：-12.0，-8.1 kg），PASI和DLQI分别维持在-2.9（95%CI：-3.9，-1.9）和-1.9（95%CI：-3.0，-0.9）。
银屑病患者长期体重减轻对银屑病严重程度有持久的积极影响。本试验已在clinicaltrials.gov注册，注册号为NCT01137188。
