Institute of Mental Health, Peking University, Beijing, China;
Swiss Med Wkly. 2013 Aug 22;143:w13838. doi: 10.4414/smw.2013.13838. eCollection 2013.
To evaluate the efficacy of combined methylphenidate and EEG feedback treatment for children with ADHD.
Forty patients with ADHD were randomly assigned to the combination group (methylphenidate therapy and EEG feedback training) or control group (methylphenidate therapy and non-feedback attention training) in a 1:1 ratio using the double-blind method. These patients, who met the DSM-IV diagnostic criteria and were aged between 7 and 16 years, had obtained optimal therapeutic effects by titrating the methylphenidate dose prior to the trial. The patients were assessed using multiple parameters at baseline, after 20 treatment sessions, after 40 treatment sessions, and in 6-month follow-up studies.
Compared to the control group, patients in the combination group had reduced ADHD symptoms and improved in related behavioural and brain functions.
The combination of EEG feedback and methylphenidate treatment is more effective than methylphenidate alone. The combined therapy is especially suitable for children and adolescents with ADHD who insufficiently respond to single drug treatment or experience drug side effects.
评估哌醋甲酯联合脑电反馈治疗注意缺陷多动障碍（ADHD）患儿的疗效。
采用双盲法将 40 例符合 DSM-IV 诊断标准的 ADHD 患儿按 1:1 比例随机分为联合组（哌醋甲酯治疗+脑电反馈训练）和对照组（哌醋甲酯治疗+非反馈注意训练）。这些 7~16 岁的患儿在入组前已通过滴定哌醋甲酯剂量获得最佳治疗效果。基线、20 次治疗后、40 次治疗后及 6 个月随访时采用多项参数对患者进行评估。
与对照组相比，联合组 ADHD 症状减轻，相关行为和脑功能改善。
脑电反馈联合哌醋甲酯治疗比单用哌醋甲酯更有效。该联合治疗尤其适用于对单药治疗反应不足或出现药物不良反应的 ADHD 患儿和青少年。
