Cortelli Sheila Cavalca, Cortelli José Roberto, Shang Hongyan, McGuire James A, Charles Christine A
Nucleus of Periodontal Research, University of Taubaté (UNITAU), São Paulo, Brazil.
Am J Dent. 2013 Jun;26(3):149-55.
This 6-month, examiner-blind, single center, randomized, parallel group, controlled clinical trial compared the antiplaque/antigingivitis effects of an alcohol-free EO mouthrinse (LISTERINE Zero) to a negative control (5% flavored, colored hydroalcohol) and to an alcohol-free CPC-containing mouthrinse (Colgate Plax).
337 gingivitis subjects were clinically examined to determine Modified Gingival Index (MGI) and Plaque Index (PI) at baseline, 3 and 6 months. The primary efficacy variables were mean MGI and mean PI at 6 months (statistically analyzed by ANCOVA). After professional dental prophylaxis, subjects were randomly assigned to 6-month twice daily unsupervised use of alcohol-free EO, alcohol-free CPC or a negative control rinse, in conjunction with normal brushing and flossing. Safety was monitored throughout the study.
311 subjects completed the study. After 6 months of use, EO significantly reduced plaque (31.6%) and gingivitis (24.0%) compared to negative control. At 6 months, CPC also significantly reduced plaque (6.4%) and gingivitis (4.4%) compared to negative control. EO provided a 26.9% decrease in plaque and a 20.5% decrease in gingivitis compared to CPC (P < 0.001). All rinses were well tolerated. The alcohol-free EO mouthrinse demonstrated superior efficacy in reducing plaque and gingivitis over 6 months compared to both negative control and alcohol-free CPC mouthrinse.
这项为期6个月、检查者盲法、单中心、随机、平行组对照临床试验，比较了不含酒精的精油漱口水（李施德林零度）与阴性对照（5%加味、染色的含醇溶液）以及不含酒精的含西吡氯铵漱口水（高露洁全效护理漱口水）的抗牙菌斑/抗牙龈炎效果。
对337名牙龈炎患者进行临床检查，在基线、3个月和6个月时测定改良牙龈指数（MGI）和菌斑指数（PI）。主要疗效变量为6个月时的平均MGI和平均PI（通过协方差分析进行统计学分析）。在进行专业牙齿洁治后，受试者被随机分配，在6个月内每天两次在无人监督的情况下使用不含酒精的精油漱口水、不含酒精的西吡氯铵漱口水或阴性对照漱口水，同时正常刷牙和使用牙线。在整个研究过程中监测安全性。
311名受试者完成了研究。使用6个月后，与阴性对照相比，精油漱口水显著减少了牙菌斑（31.6%）和牙龈炎（24.0%）。在6个月时，与阴性对照相比，西吡氯铵漱口水也显著减少了牙菌斑（6.4%）和牙龈炎（4.4%）。与西吡氯铵漱口水相比，精油漱口水使牙菌斑减少了26.9%，牙龈炎减少了20.5%（P < 0.001）。所有漱口水耐受性良好。与阴性对照和不含酒精的西吡氯铵漱口水相比，不含酒精的精油漱口水在6个月内减少牙菌斑和牙龈炎方面显示出卓越的疗效。
