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三果口漱液与姜黄口漱液治疗牙龈炎疗效的比较评价——一项随机对照研究

Comparative evaluation of the efficacy of Triphala mouthwash and Curcumin mouthwash in the treatment of gingivitis - A randomized controlled study.

作者信息

Divya Bharathi S, Aiswarya S P, Sankar Archana R

机构信息

Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, India.

Department of Periodontology, Vinayaka Mission's Sankarachariyar Dental college, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, India.

出版信息

J Oral Biol Craniofac Res. 2024 Jul-Aug;14(4):407-414. doi: 10.1016/j.jobcr.2024.05.002. Epub 2024 May 24.

DOI:10.1016/j.jobcr.2024.05.002
PMID:38832298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144734/
Abstract

BACKGROUND

Numerous studies on Triphala and Curcumin mouthwashes were analyzed individually and no study has compared the efficacy of Triphala mouthwash to Curcumin mouthwash in the management of gingivitis. Although various mouthwashes have shown reduction of plaque and gingivitis the search is still on for an ideal mouthwash with minimum side effects and better patient acceptance.

OBJECTIVES

To access the efficacy of all the mouthwashes in the management of gingivitis.

METHODS

By purposive sampling, 81 patients of both sexes with gingivitis were randomized by lottery method into 3 groups - A, B and C. Group A received scaling and Triphala mouthwash, Group B received scaling and Curcumin mouthwash and Group C underwent scaling and received Chlorhexidine mouthwash. Oral hygiene was assessed using Plaque, Gingival and Bleeding indices at baseline,7th day and 14th day. The inter-group comparisons were analysed using One-way analysis of variance (ANOVA) and multiple comparisons using Tukey's Honest significant difference test (α = 0.05) and the intra-group comparisons for the indices across various time periods within each group were analysed using Repeated-measures ANOVA and Bonferroni-adjusted pairwise comparisons post hoc test (α = 0.05). The statistical significance was set at p ≤ 0.05.

RESULTS

The study has shown that herbal mouthwashes are as effective as chlorhexidine in treating gingivitis although curcumin mouthwash showed a greater potential in reducing gingival inflammation.

CONCLUSION

Both Triphala and Curcumin mouthwashes were proven to be equally effective in reducing plaque, gingival and bleeding scores, although curcumin was better in reducing gingival inflammation. Hence herbal mouthwashes such as Triphala and Curcumin with no side effects can be considered as an alternative mouthwash to chlorhexidine.

摘要

背景

对三果木和姜黄素漱口水的众多研究进行了单独分析,尚无研究比较三果木漱口水与姜黄素漱口水在治疗牙龈炎方面的疗效。尽管各种漱口水已显示出可减少牙菌斑和牙龈炎,但仍在寻找具有最小副作用和更好患者接受度的理想漱口水。

目的

评估所有漱口水在治疗牙龈炎方面的疗效。

方法

通过目的抽样,将81例患有牙龈炎的男女患者通过抽签法随机分为3组——A组、B组和C组。A组接受洗牙和三果木漱口水,B组接受洗牙和姜黄素漱口水,C组接受洗牙并使用氯己定漱口水。在基线、第7天和第14天使用牙菌斑、牙龈和出血指数评估口腔卫生状况。组间比较采用单因素方差分析(ANOVA),多重比较采用Tukey诚实显著差异检验(α = 0.05),每组内不同时间段指标的组内比较采用重复测量方差分析和Bonferroni校正的事后两两比较检验(α = 0.05)。统计学显著性设定为p≤0.05。

结果

研究表明,草药漱口水在治疗牙龈炎方面与氯己定一样有效,尽管姜黄素漱口水在减轻牙龈炎症方面显示出更大的潜力。

结论

三果木和姜黄素漱口水在降低牙菌斑、牙龈和出血评分方面均被证明同样有效,尽管姜黄素在减轻牙龈炎症方面更好。因此,三果木和姜黄素等无副作用的草药漱口水可被视为氯己定的替代漱口水。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/846f83e48ea3/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/5dbb2196894e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/6471c52c660e/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/42df475fcfcc/gr2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/580c841cae3e/gr3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/846f83e48ea3/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/5dbb2196894e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/6471c52c660e/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/42df475fcfcc/gr2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/580c841cae3e/gr3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f370/11144734/846f83e48ea3/fx1.jpg

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Adv Exp Med Biol. 2021;1291:179-211. doi: 10.1007/978-3-030-56153-6_11.
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Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential.姜黄素的药理学性质及其潜在机制和药用潜力的展望。
Biomed Pharmacother. 2021 Sep;141:111888. doi: 10.1016/j.biopha.2021.111888. Epub 2021 Jul 5.
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Clinical efficacy of curcumin versus chlorhexidine as an adjunct to scaling and root planing for the treatment of periodontitis: A systematic review and meta-analysis.
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