[Impact of virus infection and related immunity factorson nasal inverted papilloma].

To explore the relationship between human papilloma virus infection,TGF-β,IL-10,IFN-γand nasal inverted papilloma.To explore the relat-ionship between human papilloma virus infection,TGF-β,IL-10,IFN-γand nasal squamous cell carcinoma.Thirty cases of NIP(including 7 cases of recurrent NIP),23 cases of NSCC,19 cases of NP were collected.In situ hybridization(ISH) was used to detect the infection of HPV6/11,HPV16/18.Immunohistochemical technique(EnVision) was used to detect the expression of TGF-β,IL-10,IFN-γ.The HPV infection rates of 30 cases of NIP,23 cases of NSCC were 43.33%,52.17%.None of the NP cases was infected with HPV.Nine out of 23 cases of primary NIP were positive in HPV infection (39.13%).Three out of 7 cases of recurrent NIP were positive in HPV infection (42.86%).There were significant differences in the HPV infection rate between NIP and NP as well as between NSCC and NP(<0.05).No significant difference of HPV infection rate was observed between NIP and NSCC or between recurrent NIP and primary NIP(>0.05).TGF-β,IL-10,IFN-γwere expressed in NSCC,NIP and NP.The expression of TGF-βwas significantly different among NIP,NSCC and NP(<0.01).The expression of TGF-βin NIP group was higher than that in NP and NSCC group.There was no significant difference of TGF-βexpression between NSCC and NP group .The expression of IL-10 was significantly different among NIP,NSCC and NP(<0.01).The expression of IL-10 in NIP group was lower than that in NP group.There was no significant difference in IL-10 expression between NIP and NSCC or between NSCC and NP.No significant differences of IFN-γexpression was observed among NIP,NSCC and NP(>0.05).There was no correlation between the expression of TGF-β,IL-10,IFN-γand HPV infection in NIP and NSCC(>0.05).HPV infection is related to the pathogenesis of some NIP and NSCC cases.The relationship of between HPV infection and malignance of NIP is not clear.HPV infection is not related to the recurrence of NIP.Abnormal expression TGF-βand IL-10 may be involved in the pathogenesis of NIP.There is no relationship between IFN-γand the pathogenesis and development of NIP.HPV infection is not related with the expression of TGF-β,IL-10,IFN-γin NIP and NSCC.