日本野桐茎中的劳丹烷二萜。

ent-Labdane diterpenes from the stems of Mallotus japonicus.

机构信息

State Key Laboratory of Drug Research & SIMM-CUHK Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu-Chong-Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2013 Sep 27;76(9):1580-5. doi: 10.1021/np400241p. Epub 2013 Aug 30.

DOI:10.1021/np400241p

PMID:23987741

Abstract

Eight new ent-labdane diterpenoids, mallonicusins A-H (1-8), were isolated from the stems of Mallotus japonicus. Their structures, including the absolute configurations, were determined by extensive analyses of spectroscopic data and the ECD spectra of the Pr(FOD)₃ complex of substrates in CCl₄. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallography using Cu Kα radiation.

摘要

从中国野桐的茎中分离得到了 8 个新的 Ent-labdane 二萜类化合物，命名为 mallonicusins A-H（1-8）。通过对光谱数据的广泛分析以及在 CCl₄中 Pr(FOD)₃复合物的 ECD 光谱的分析，确定了它们的结构，包括绝对构型。通过 Cu Kα 辐射的单晶 X 射线晶体学确定了化合物 1 的绝对构型。