Amomaxins A 和 B，两种来自阳春砂的具有九元环的全新骨架的裂环二萜，属于 rearranged labdane norditerpenoids。

Amomaxins A and B, two unprecedented rearranged labdane norditerpenoids with a nine-membered ring from Amomum maximum.

机构信息

State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

Org Lett. 2013 Apr 5;15(7):1572-5. doi: 10.1021/ol400348a. Epub 2013 Mar 8.

DOI:10.1021/ol400348a

PMID:23472989

Abstract

Amomaxins A (1) and B (2), featuring an unprecedented rearranged labdane norditerpene skeleton with a nine-membered ring, along with their biosynthetic related known compound isocoronarin D (3) were isolated from the roots of Amomum maximum. Their structures with absolute configurations were determined by spectroscopic data, CD experimentation, and single-crystal X-ray diffraction. Compound 2 showed an inhibitory effect on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.

摘要

从大高良姜的根部分离得到了 Amomaxins A（1）和 B（2），它们具有前所未有的重排的 labdane 降二萜骨架和一个九元环，以及它们的生物合成相关的已知化合物异 Coronarin D（3）。通过光谱数据、CD 实验和单晶 X 射线衍射确定了它们的结构和绝对构型。化合物 2 对脂多糖诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）的产生具有抑制作用。