来自宽叶金粟兰全草的具有生物活性的对映-海松烷型和对映-松香烷型二萜类化合物。
Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi.
作者信息
Xie Chunfeng, Sun Lingmei, Liao Kai, Liu Sheng, Wang Meicheng, Xu Jing, Bartlam Mark, Guo Yuanqiang
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
出版信息
J Nat Prod. 2015 Nov 25;78(11):2800-7. doi: 10.1021/acs.jnatprod.5b00781. Epub 2015 Nov 11.
Two new ent-pimarane (1 and 2), eight new ent-abietane (3-10) diterpenoids, and eight known analogues (11-18) were isolated from the whole plants of Chloranthus henryi. The absolute configuration of 1 was determined on the basis of single-crystal X-ray diffraction data. Compound 8 represents a class of rare naturally occurring C-14 norabietanes, and compounds 9 and 10 feature rare 13,14-seco-abietane skeletons. Compounds 5, 12, 13, and 15 inhibited the yeast-to-hyphae transition of Candida albicans with IC50 values between 97.3 and 738.7 μM.
从宽叶金粟兰全草中分离得到两个新的对映-海松烷型二萜（1和2）、八个新的对映-贝壳杉烷型二萜（3-10）以及八个已知类似物（11-18）。基于单晶X射线衍射数据确定了1的绝对构型。化合物8代表一类罕见的天然存在的C-14去甲贝壳杉烷型二萜，化合物9和10具有罕见的13,14-裂贝壳杉烷骨架。化合物5、12、13和15抑制白色念珠菌由酵母型向菌丝型转变，IC50值在97.3至738.7 μM之间。
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