University Institute of Tropical Diseases and Public Health of The Canary Islands, University of La Laguna, Avenida Astrofísico Francisco Sánchez SN, 38203 La Laguna, Tenerife, Canary Islands, Spain.
Trends Parasitol. 2013 Oct;29(10):483-8. doi: 10.1016/j.pt.2013.07.009. Epub 2013 Aug 26.
Balamuthia mandrillaris is an opportunistic, free-living amoeba that can cause skin lesions and the typically fatal Balamuthia amoebic encephalitis (BAE) both in immunocompromised and immunocompetent individuals. Available data for BAE cases indicate that this disease is difficult to detect because knowledge of predisposing factors is lacking, causing a challenge for diagnosing BAE. The number of reported BAE cases is increasing worldwide, and this is a major concern because little is known about the pathogen, no standardized detection tools are available, and most of the treatments are almost empirical. The recently reported cases, novel diagnostics tools, and successful therapeutic approaches against BAE infections are reviewed here.
曼氏迭宫绦虫是一种机会主义的自由生活的变形虫，它可以在免疫功能低下和免疫功能正常的个体中引起皮肤损伤和典型的致命曼氏迭宫绦虫阿米巴脑炎（BAE）。现有的 BAE 病例数据表明，这种疾病很难被发现，因为缺乏发病因素的知识，这给 BAE 的诊断带来了挑战。全球报告的 BAE 病例数量正在增加，这是一个主要的关注点，因为人们对病原体知之甚少，没有可用的标准化检测工具，而且大多数治疗方法几乎都是经验性的。本文回顾了最近报道的 BAE 感染病例、新型诊断工具和成功的治疗方法。
