Aboubechara John Paul, Kantamneni Trishna, Pasao Katrina
Department of Neurology, University of California, Davis, Davis, CA, USA.
J Child Neurol. 2025 May;40(5):366-370. doi: 10.1177/08830738241307058. Epub 2024 Dec 19.
granulomatous amebic encephalitis is a rare disease that is associated with a high rate of mortality. Delays in diagnosis and treatment are common because of limited information on the organism in addition to its nonspecific clinical presentation. Prior reports have demonstrated that the encephalitis presents as multifocal lesions throughout the central nervous system with enhancement and edema. Here we report a case involving a 4-year-old previously healthy female child with a novel pathologic presentation of infection, including vasculitis involving multiple large intracranial vessels as well as inflammation of multiple cranial nerves. The infection was ultimately fatal despite early diagnosis and initiation of targeted treatment.
肉芽肿性阿米巴脑炎是一种罕见疾病，死亡率很高。由于关于该病原体的信息有限，加上其临床表现不具特异性，诊断和治疗往往会出现延误。既往报告显示，该脑炎表现为中枢神经系统多处出现伴有强化和水肿的病灶。我们在此报告一例病例，患者为一名4岁以前健康的女童，出现了该感染的一种新的病理表现，包括累及多条颅内大血管的血管炎以及多条颅神经的炎症。尽管早期诊断并开始了针对性治疗，但该感染最终仍导致死亡。
