Division of Gynaecological Oncology, Department of Gynaecology-Obstetrics, Cancer Institute, University Hospital Leuven, Leuven, Belgium.
Gynecol Oncol. 2013 Dec;131(3):694-700. doi: 10.1016/j.ygyno.2013.08.020. Epub 2013 Aug 27.
To prospectively assess the value of PET/CT for staging, diagnosis and operability of ovarian cancer, with special attention to the peritoneal spread.
From June 2009 to March 2011, 69 patients with suspicion of having an ovarian cancer underwent an (18)F-FDG PET/CT. To identify the diagnostic value of PET/CT, the results were compared with the findings at diagnostic laparoscopy and/or debulking surgery.
There were 56 patients with malignant tumors and 13 with benign tumors. We observed a sensitivity and specificity of 93% and 77%, respectively for malignant tumors with PET/CT. CT alone had a sensitivity and specificity of 96% and 38%, respectively. The overall FIGO classification evaluation for PET/CT and CT were the same. For the evaluation of metastases, the sensitivity of PET/CT was worse, while the specificity was better than CT. Retroperitoneal lymph node metastases were diagnosed better with PET/CT, while there was no difference for peritoneal spread and for the intestines. PET/CT detected another unknown primary tumor in 3 (4.3%) cases.
PET/CT is better than CT in detecting retroperitoneal lymph node metastases, but not for peritoneal metastases.
前瞻性评估 PET/CT 对卵巢癌分期、诊断和可切除性的价值，特别关注腹膜扩散。
2009 年 6 月至 2011 年 3 月，69 例疑似卵巢癌患者接受了（18）F-FDG PET/CT 检查。为了确定 PET/CT 的诊断价值，将检查结果与诊断性腹腔镜检查和/或肿瘤减灭术的结果进行比较。
56 例患者为恶性肿瘤，13 例为良性肿瘤。我们观察到 PET/CT 对恶性肿瘤的敏感性和特异性分别为 93%和 77%。CT 单独检查的敏感性和特异性分别为 96%和 38%。PET/CT 和 CT 的总体 FIGO 分期评估相同。对于转移的评估，PET/CT 的敏感性较差，但特异性优于 CT。PET/CT 能更好地诊断腹膜后淋巴结转移，而对腹膜扩散和肠道无差异。PET/CT 在 3 例（4.3%）患者中发现了另一个未知的原发性肿瘤。
与 CT 相比，PET/CT 在检测腹膜后淋巴结转移方面更有效，但在检测腹膜转移方面效果不佳。
