按蚊的先天免疫系统在抵御疟疾感染中的作用。
The Anopheles innate immune system in the defense against malaria infection.
作者信息
Clayton April M, Dong Yuemei, Dimopoulos George
机构信息
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md., USA.
出版信息
J Innate Immun. 2014;6(2):169-81. doi: 10.1159/000353602. Epub 2013 Aug 28.
Abstract
The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.
摘要
昆虫多层面的先天免疫系统能够抵抗包括导致人类疟疾的病原体在内的多种病原体的感染。按蚊传播疟疾取决于疟原虫在昆虫媒介中成功完成其生命周期，这一过程涉及与多个组织和细胞类型以及与蚊子先天免疫系统的相互作用。本综述将讨论我们目前对按蚊针对疟原虫的先天免疫反应以及昆虫肠道微生物群对寄生虫感染的影响的理解。
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