Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, Japan.
Ophthalmologica. 2013;230(3):138-43. doi: 10.1159/000351661. Epub 2013 Aug 24.
To evaluate whether indocyanine green (ICG)-assisted internal limiting membrane peeling affects visual outcome and macular morphologic changes in spectral-domain optical coherence tomography images after macular hole (MH) surgery.
A retrospective analysis was performed of 34 eyes in 34 patients who had undergone surgical treatment for MH. Best-corrected visual acuity (BCVA) and optical coherence tomography parameters including central foveal thickness, length of the external limiting membrane (ELM) defect, and length of the inner segment and outer segment (IS/OS) defect were analyzed pre- and postoperatively.
The eyes were divided into 2 groups based on ICG use (ICG+/-). The changes in BCVA did not differ significantly between the 2 groups at 6 months. However, the ICG+ group had poorer changes compared with the ICG- group at 1 and 3 months (p = 0.038, p = 0.012, respectively). Central foveal thickness and ELM defect did not differ between the 2 groups at each period. The IS/OS defect in the ICG+ group was significantly greater at 1 and 3 months than that in the ICG- group (p = 0.026, p = 0.048, respectively).
ICG staining may affect the recovery process of macular morphology and visual acuity in the first several months after MH surgery.
评估吲哚菁绿（ICG）辅助内界膜剥离对孔源性黄斑裂孔（MH）手术后黄斑区形态和光谱域光学相干断层扫描（SD-OCT）图像的影响。
回顾性分析了 34 例 34 只眼接受 MH 手术治疗的患者。分析术前和术后最佳矫正视力（BCVA）和 OCT 参数，包括中心凹视网膜厚度、外节膜（ELM）缺损长度和内节/外节（IS/OS）缺损长度。
根据是否使用 ICG（ICG+/-）将眼分为两组。两组术后 6 个月 BCVA 变化无显著差异。但与 ICG-组相比，ICG+组在术后 1 个月和 3 个月时 BCVA 变化更差（p=0.038，p=0.012）。两组各期中心凹视网膜厚度和 ELM 缺损无显著差异。ICG+组在术后 1 个月和 3 个月时 IS/OS 缺损显著大于 ICG-组（p=0.026，p=0.048）。
ICG 染色可能影响 MH 手术后数月内黄斑形态和视力的恢复过程。
