Oral Health and Society Unit, Faculty of Dentistry, McGill University, Montreal, Que., Canada.
Horm Res Paediatr. 2013;80(3):154-62. doi: 10.1159/000354043. Epub 2013 Aug 28.
BACKGROUND/AIMS: Childhood and adolescence are critical periods for bone growth. The independent association between lean and fat mass and indicators of bone health in children is not yet known. We aim to examine the association between each of lean and fat mass and indicators of bone health in 8- to 10-year-old prepubertal Caucasian children.
We present a cross-sectional analysis of baseline data from the QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) cohort which study the natural history of obesity. Study participants (n = 483) included prepubertal children aged 8-10 years and their biological parents. Whole-body bone mineral content (BMC, g), bone area (cm²), bone mineral density (BMD, g/cm²), lean mass (kg), and fat mass (kg) were measured by dual-energy X-ray absorptiometry. Data analyses include multiple linear regressions adjusted for potential confounding variables.
A 1-kg increase in lean mass was associated with 28.42 g, 19.88 cm², and 0.007 g/cm² increase in whole-body BMC, bone area and BMD respectively. A 1-kg increase in fat mass was associated with 9.32 g, 8.02 cm², and 0.002 g/cm² increase in whole-body BMC, bone area and BMD, respectively.
Increasing lean mass in children may help optimize bone acquisition and prevent future osteoporosis.
背景/目的：儿童期和青春期是骨骼生长的关键时期。瘦体重和脂肪量与儿童骨骼健康指标之间的独立关联尚不清楚。我们旨在研究 8-10 岁青春期前白种人儿童的瘦体重和脂肪量与骨骼健康指标之间的关联。
我们对肥胖自然史研究的魁北克脂肪和生活方式青少年调查（QUALITY）队列的基线数据进行了横断面分析。研究参与者（n=483）包括 8-10 岁的青春期前儿童及其亲生父母。全身骨矿物质含量（BMC，g）、骨面积（cm²）、骨矿物质密度（BMD，g/cm²）、瘦体重（kg）和脂肪量（kg）通过双能 X 射线吸收法测量。数据分析包括了对潜在混杂变量进行调整的多元线性回归。
瘦体重每增加 1kg，全身 BMC、骨面积和 BMD 分别增加 28.42g、19.88cm²和 0.007g/cm²。脂肪量每增加 1kg，全身 BMC、骨面积和 BMD 分别增加 9.32g、8.02cm²和 0.002g/cm²。
增加儿童的瘦体重可能有助于优化骨骼获得并预防未来的骨质疏松症。
