Steinbrugger B, Zach M
Universitäts-Kinderklinik Graz.
Monatsschr Kinderheilkd. 1990 Jul;138(7):389-91.
More than half of the pediatric asthma population will become symptomfree during adolescence. We evaluated non-specific airway reactivity by cold air challenge in 42 symptomfree asthma patients, age 8 to 18 years, one year after termination of their anti-asthmatic medication. Twenty-one patients showed a normalized bronchial reactivity, 16 were found to be hyperreactive, and 5 presented with a borderline response. When compared to the normoreactive group, the hyperreactive subjects showed the following statistically significant differences: 1) more allergy by RAST and history (16/16 vs 14/21, p less than 0.05); 2) a significant reduction of mid- and endexpiratory flowrates in baseline lung-function measurements (% pred); maximum expiratory flow at 50% vital capacity: 75% vs 96%, p less than 0.01; maximum expiratory flow at 25% of vital capacity: 71% vs 102%, p less than 0.005). In conclusion, more than one third of our clinically symptom-free patients showed persisting bronchial hyperreactivity; 50% presented with a normalised bronchial response.
超过半数的儿童哮喘患者在青春期症状会消失。我们对42名年龄在8至18岁、停用抗哮喘药物一年且无症状的哮喘患者进行了冷空气激发试验，以评估其非特异性气道反应性。21名患者支气管反应性恢复正常，16名患者反应性过高，5名患者反应处于临界状态。与反应正常组相比，反应过高组有以下统计学上的显著差异：1）通过放射变应原吸附试验和病史显示过敏更多（16/16对14/21，p<0.05）；2）基线肺功能测量中呼气中期和末期流速显著降低（预计值%）；肺活量50%时的最大呼气流量：75%对96%，p<0.01；肺活量25%时的最大呼气流量：71%对102%，p<0.005。总之，我们临床上无症状的患者中超过三分之一显示支气管高反应性持续存在；50%的患者支气管反应恢复正常。
