孟加拉国母婴定植：流行率、病因和危险因素。

Maternal and neonatal colonization in Bangladesh: prevalences, etiologies and risk factors.

机构信息

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

出版信息

J Perinatol. 2013 Dec;33(12):971-6. doi: 10.1038/jp.2013.99. Epub 2013 Aug 29.

DOI:10.1038/jp.2013.99

PMID:23989196

Abstract

OBJECTIVE

To estimate the prevalence of maternal colonizers in South Asia and their potential to colonize the umbilicus, an important precondition causing neonatal sepsis.

STUDY DESIGN

We conducted a cross-sectional study at a maternity center in Dhaka with 1219 pregnant women and a subset of 152 newborns from 15 January to 31 October 2011. During labor, study paramedics collected vaginal swabs for bacterial culture and rectal swabs for Group B Streptococcus (GBS) testing. Community health workers collected neonatal umbilical swabs. Log-binomial regression models were used to estimate risk ratios.

RESULT

In all, 454 women (37.2%, 95% confidence interval (CI) 34.5 to 40.0%) were colonized. The most common organisms isolated were Staphylococcus aureus, Non-GBS and GBS. A total of 94 women (7.7%, 95% CI 6.2 to 9.2%) were colonized with GBS. The risk of GBS umbilical colonization was higher (RR=12.98, 95% CI 3.97 to 42.64) among newborns of mothers with GBS colonization.

CONCLUSION

Newborns of mothers colonized with GBS are at higher risk of developing umbilical colonization.

摘要

目的

估计南亚产妇定植者的流行率及其定植脐部的潜力，脐部是导致新生儿败血症的重要先决条件。

研究设计

我们于 2011 年 1 月 15 日至 10 月 31 日在达卡的一家妇产科中心进行了一项横断面研究，共有 1219 名孕妇和 152 名新生儿亚组。在分娩过程中，研究辅助人员采集了阴道拭子进行细菌培养和直肠拭子进行 B 组链球菌（GBS）检测。社区卫生工作者采集了新生儿脐部拭子。使用对数二项式回归模型估计风险比。

结果

共有 454 名女性（37.2%，95%置信区间 34.5%至 40.0%）定植。最常见的分离菌为金黄色葡萄球菌、非 GBS 和 GBS。共有 94 名女性（7.7%，95%置信区间 6.2%至 9.2%）定植 GBS。GBS 定植的母亲所生新生儿的 GBS 脐部定植风险更高（RR=12.98，95%置信区间 3.97 至 42.64）。