Bojang Abdoulie, Kendall Lindsay, Usuf Effua, Egere Uzochukwu, Mulwa Sarah, Antonio Martin, Greenwood Brian, Hill Philip C, Roca Anna
Medical Research Council Unit, P. O. Box 273, Fajara, The Gambia.
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
BMC Infect Dis. 2017 Aug 25;17(1):588. doi: 10.1186/s12879-017-2685-1.
We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage.
Two hundred thirty-two children aged 5-10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS). S. aureus was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression.
Prevalence of S. aureus carriage was 25.9%. In the univariable analysis, prevalence of S. aureus carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)]. S. aureus carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of S. pneumoniae did not have any effect on S. aureus carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of S. aureus observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61-4.60) and not in the dry season OR 1.28 95%CI (0.78-2.09).
Prevalence of nasopharyngeal carriage of S. aureus among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of S. aureus is not associated with carriage of S. pneumoniae.
ISRCTN51695599 . Registered August 04th 2006.
我们在参与了冈比亚农村地区一项群组随机PCV-7试验的个体中开展了一项辅助研究（部分群组全部接种了疫苗，而其他群组中只有幼儿接种了疫苗），以确定金黄色葡萄球菌鼻咽部携带的患病率及危险因素。
招募了232名5至10岁的儿童，在疫苗接种开始后的4至20个月进行随访。我们收集了1264份鼻咽拭子（NPS）。采用传统微生物学方法分离金黄色葡萄球菌。通过逻辑回归评估携带的危险因素。
金黄色葡萄球菌携带率为25.9%。在单变量分析中，在PCV-7全接种村庄居住的儿童中金黄色葡萄球菌携带率更高[比值比（OR）=1.57，95%置信区间（CI）（1.14至2.15）]，以及至少接受过1年教育的儿童中[OR=1.44，95%CI（1.07至1.92）]。在雨季金黄色葡萄球菌携带率也更高[OR=1.59，95%CI（1.20至2.11）]。对于任何肺炎球菌、疫苗型（VT）或非疫苗型（NVT）携带情况，肺炎链球菌携带对金黄色葡萄球菌携带均无影响。多变量分析显示，在PCV-7全接种村庄居住的儿童中观察到的金黄色葡萄球菌较高携带率仅在雨季出现[OR=2.72，95%CI（1.61 - 4.60）]，而在旱季未出现[OR=1.28，95%CI（0.78 - 2.09）]。
在PCV-7全接种社区居住的冈比亚儿童中，雨季期间金黄色葡萄球菌鼻咽部携带率升高。然而，金黄色葡萄球菌携带与肺炎链球菌携带无关。
ISRCTN51695599。于2006年8月4日注册。
