Gabard-Durnam Laurel, Tierney Adrienne L, Vogel-Farley Vanessa, Tager-Flusberg Helen, Nelson Charles A
Harvard College, Cambridge, MA, 02115, USA.
J Autism Dev Disord. 2015 Feb;45(2):473-80. doi: 10.1007/s10803-013-1926-4.
An emerging focus of research on autism spectrum disorder (ASD) targets the identification of early-developing ASD endophenotypes using infant siblings of affected children. One potential neural endophenotype is resting frontal electroencephalogram (EEG) alpha asymmetry, a metric of hemispheric organization. Here, we examined the development of frontal EEG alpha asymmetry in ASD high-risk and low-risk infant populations. Our findings demonstrate that low and high-risk infants show different patterns of alpha asymmetry at 6 months of age and opposite growth trajectories in asymmetry over the following 12 months. These results support the candidacy of alpha asymmetry as an early neural ASD endophenotype.
自闭症谱系障碍（ASD）研究的一个新重点是利用患病儿童的婴儿兄弟姐妹来识别早期出现的ASD内表型。一种潜在的神经内表型是静息额叶脑电图（EEG）α波不对称性，这是一种半球组织的指标。在此，我们研究了ASD高风险和低风险婴儿群体中额叶EEGα波不对称性的发展情况。我们的研究结果表明，低风险和高风险婴儿在6个月大时表现出不同的α波不对称模式，并且在接下来的12个月中不对称性的增长轨迹相反。这些结果支持了α波不对称作为早期神经ASD内表型的候选资格。
