Kaiser Andreas K, Doppelmayr Michael, Iglseder Bernhard
Department of Geriatric Medicine, Salzburger Landeskliniken Betriebs GesmbH, Christian-Doppler-Klinik, Paracelsus Medical University Salzburg, Ignaz-Harrer-Straße 79, 5020, Salzburg, Österreich.
Department of Clinical Psychology, Salzburger Landeskliniken Betriebs GesmbH, Christian-Doppler-Klinik, Paracelsus Medical University Salzburg, Salzburg, Österreich.
Z Gerontol Geriatr. 2018 Feb;51(2):200-205. doi: 10.1007/s00391-016-1108-z. Epub 2016 Jul 15.
A correlation between asymmetry in electroencephalographs (EEG) and depression has been demonstrated in many studies. To the best of our knowledge there are no studies including oldest old geriatric patients.
The objective of this study was to evaluate whether frontal and parietal alpha asymmetry can be used to differentiate between depressed and control patients in a cohort sample with a mean age of 80 years.
Differences in the EEG were investigated in 39 right-handed female geriatric patients (mean age 80 years) with respect to frontal alpha asymmetry (FAA) and parietal alpha asymmetry (PAA) in depression (n = 14), depression combined with anxiety (n = 11) and normal controls (n = 14) as assessed with the hospital anxiety and depression scale (HADS). Band power was calculated for alpha 1 (6.9-8.9 Hz), alpha 2 (8.9-10.9 Hz) and alpha 3 bands (10.9-12.9 Hz). Furthermore, correlations between frontal and parietal alpha asymmetry and the geriatric depression scale (GDS), the HADS and the mini mental state examination (MMSE) were calculated.
A differentiation between the three groups was not possible with FAA and PAA. Significant correlations were found between PAA alpha 3 band and anxiety and depression.
The alpha asymmetry in EEG seemed to disappear with age. Correlations between PAA and anxiety and depression were found. The results are in line with the right (hemisphere) hemi-aging hypothesis.
许多研究已证实脑电图（EEG）不对称与抑郁症之间存在关联。据我们所知，尚无针对高龄老年患者的研究。
本研究的目的是评估在平均年龄为80岁的队列样本中，额叶和顶叶α波不对称是否可用于区分抑郁症患者和对照患者。
使用医院焦虑抑郁量表（HADS）对39名右利手老年女性患者（平均年龄80岁）进行研究，这些患者被分为抑郁症组（n = 14）、抑郁合并焦虑组（n = 11）和正常对照组（n = 14），研究其EEG在额叶α波不对称（FAA）和顶叶α波不对称（PAA）方面的差异。计算α1（6.9 - 8.9Hz）、α2（8.9 - 10.9Hz）和α3频段（10.9 - 12.9Hz）的频段功率。此外，还计算了额叶和顶叶α波不对称与老年抑郁量表（GDS）、HADS和简易精神状态检查表（MMSE）之间的相关性。
FAA和PAA无法区分这三组。发现PAA的α3频段与焦虑和抑郁之间存在显著相关性。
EEG中的α波不对称似乎随年龄增长而消失。发现PAA与焦虑和抑郁之间存在相关性。结果符合右侧（半球）半老化假说。
