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本文引用的文献

1
Return of results in translational iPS cell research: considerations for donor informed consent.转化性诱导多能干细胞研究中的结果反馈：供体知情同意的考量
Stem Cell Res Ther. 2013 Jan 21;4(1):6. doi: 10.1186/scrt154.
2
Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent.诱导多能干细胞研究的标本采集：协调知情同意书的方法。
Stem Cells Transl Med. 2012 May;1(5):409-21. doi: 10.5966/sctm.2012-0029. Epub 2012 May 8.
3
Disclosure and management of research findings in stem cell research and banking: policy statement.干细胞研究和储存中研究结果的披露和管理：政策声明。
Regen Med. 2012 May;7(3):439-48. doi: 10.2217/rme.12.23.
4
Sustained interaction: the new normal for stem cell repositories?持续互动：干细胞库的新常态？
Regen Med. 2011 Nov;6(6):783-92. doi: 10.2217/rme.11.93.
5
Stem cell policy exceptionalism: proceed with caution.干细胞政策的例外主义：谨慎行事。
Stem Cell Rev Rep. 2012 Jun;8(2):299-304. doi: 10.1007/s12015-011-9305-z.
6
Publishing SNP genotypes of human embryonic stem cell lines: policy statement of the International Stem Cell Forum Ethics Working Party.发布人类胚胎干细胞系的 SNP 基因型：国际干细胞论坛伦理工作组政策声明。
Stem Cell Rev Rep. 2011 Sep;7(3):482-4. doi: 10.1007/s12015-010-9226-2.
7
Governing stem cell banks and registries: emerging issues.管理干细胞库和登记处：新出现的问题。
Stem Cell Res. 2009 Sep-Nov;3(2-3):96-105. doi: 10.1016/j.scr.2009.05.003. Epub 2009 May 25.

DISCUSS 项目：从先前收集的研究生物样本中诱导多能干细胞系和知情同意：需要考虑的要点。

The DISCUSS Project: induced pluripotent stem cell lines from previously collected research biospecimens and informed consent: points to consider.

机构信息

California Institute for Regenerative Medicine, San Francisco, California, USA.

出版信息

Stem Cells Transl Med. 2013 Oct;2(10):727-30. doi: 10.5966/sctm.2013-0099. Epub 2013 Aug 29.

DOI:10.5966/sctm.2013-0099
PMID:23990574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3785257/
Abstract

Human somatic cell reprogramming is a leading technology for accelerating disease modeling and drug discovery. Research organizations are sponsoring initiatives to create libraries of induced pluripotent stem cell (iPSC) lines for broad distribution and application. Donor informed consent plays a critical role in supporting the ethical conduct of iPSC research. To date, our organizations have focused on informed consent considerations for somatic cell collection intended specifically for iPSC derivation and distribution. This article considers how somatic cells obtained under general (biomedical) research protocols can be used for iPSC derivation. We present draft Points to Consider regarding the use of human somatic cells for iPSC research. Our goal is to initiate a process designed to develop consensus for the use of previously collected specimens for iPSC research. We anticipate publishing final considerations in early 2014.

摘要

人类体细胞重编程是加速疾病建模和药物发现的领先技术。研究机构正在发起倡议，创建诱导多能干细胞（iPSC）系库，以供广泛分发和应用。供体知情同意在支持 iPSC 研究的伦理行为方面发挥着关键作用。迄今为止，我们的组织一直专注于体细胞采集的知情同意考虑，这些采集专门用于 iPSC 的衍生和分配。本文考虑了如何使用一般（生物医学）研究方案获得的体细胞来衍生 iPSC。我们提出了关于使用人类体细胞进行 iPSC 研究的草案要点。我们的目标是启动一个旨在就先前收集的标本用于 iPSC 研究达成共识的过程。我们预计在 2014 年初发布最终考虑。