关于基于干细胞治疗阿尔茨海默病的当前观点
Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease.
作者信息
Kwak Kyeong-Ah, Lee Seung-Pyo, Yang Jin-Young, Park Young-Seok
机构信息
Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Department of Dental Hygiene, Daejeon Institute of Science and Technology, Daejeon, Republic of Korea.
出版信息
Stem Cells Int. 2018 Mar 1;2018:6392986. doi: 10.1155/2018/6392986. eCollection 2018.
Alzheimer's disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease's pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.
阿尔茨海默病（AD）是一种以记忆丧失和认知障碍为特征的进行性神经退行性疾病，由突触功能障碍和错误折叠蛋白的过度积累引起。人们曾多次尝试开发新的小分子或抗体来干预该疾病的发病机制，但均未成功。基于干细胞的疗法作为一种替代或再生策略，为AD治疗带来了新的希望。最近关于基于干细胞疗法的临床前研究结果很有前景。目前人类临床试验正在进行中。然而，在安全有效的临床转化之前，仍有许多问题有待解答。本综述探讨了AD的病理生理学，并根据细胞类型总结了相关的干细胞研究。我们还简要总结了相关的临床试验。最后，讨论了它们临床应用的未来前景。
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