Fraunhofer UK Research Ltd, Glasgow, UK.
Fraunhofer Institute for Biomedical Engineering (IBMT), Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach, Germany.
Stem Cell Reports. 2021 Aug 10;16(8):1853-1867. doi: 10.1016/j.stemcr.2021.07.009.
Disease-relevant human induced pluripotent stem cells (iPSCs) are generated worldwide for research purposes; however, without robust and practical ethical, legal, and quality standards, there is a high risk that their true potential will not be realized. Best practices for tissue procurement, iPSC reprogramming, day-to-day cultivation, quality control, and data management aligned with an ethical and legal framework must be included into daily operations to ensure their promise is maximized. Here we discuss key learning experiences from 7 years of operating the European Bank for induced Pluripotent Stem Cells (EBiSC) and recommend how to incorporate solutions into a daily management framework.
用于研究目的的疾病相关人类诱导多能干细胞（iPSC）在全球范围内生成；然而，如果没有强大而实用的伦理、法律和质量标准，它们的真正潜力将无法实现。必须将组织采购、iPSC 重编程、日常培养、质量控制和数据管理的最佳实践与伦理和法律框架相结合，纳入日常运营，以确保最大限度地发挥其潜力。在这里，我们讨论了运营欧洲诱导多能干细胞银行（EBiSC）7 年来的关键经验教训，并建议如何将解决方案纳入日常管理框架。
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