Department of Respiration, Nanfang Hospital of Southern Medical University, Guangzhou, China.
PLoS One. 2013 Aug 26;8(8):e68457. doi: 10.1371/journal.pone.0068457. eCollection 2013.
Many studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln, Arg194Trp, Arg280His, -77T>C, and X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphisms with lung cancer risk, but the results remained controversial. Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases and 16,667 controls from 41 studies), Arg194Trp (7,426 cases and 9,603 controls from 23 studies), Arg280His (6,211 cases and 6,763 controls from 16 studies), -77T>C (2,487 cases and 2,576 controls from 5 studies), and XRCC3 T241M (8,560 cases and 11,557 controls from 19 studies) in different inheritance models. We found that -77T>C polymorphism was associated with increased lung cancer risk (dominant model: odds ration [OR] = 1.45, 95% confidence interval [CI] = 1.27-1.66, recessive model: OR = 1.73, 95% CI = 1.14-2.62, additive model: OR = 1.91, 95% CI = 1.24-1.94) when all the eligible studies were pooled into the meta-analysis. In the stratified and sensitive analyses, significantly decreased lung cancer risk was observed in overall analysis (dominant model: OR = 0.83, 95% CI = 0.78-0.89; recessive model: OR = 0.90, 95% CI = 0.81-1.00; additive model: OR = 0.82, 95% CI = 0.74-0.92), Caucasians (dominant model: OR = 0.82, 95% CI = 0.76-0.87; recessive model: OR = 0.89, 95% CI = 0.80-0.99; additive model: OR = 0.81, 95% CI = 0.73-0.91), and hospital-based controls (dominant model: OR = 0.81, 95% CI = 0.76-0.88; recessive model: OR = 0.89, 95% CI = 0.79-1.00; additive model: OR = 0.80, 95% CI = 0.71-0.90) for XRCC3 T241M. In conclusion, this meta-analysis indicates that XRCC1 -77T>C shows an increased lung cancer risk and XRCC3 T241M polymorphism is associated with decreased lung cancer risk, especially in Caucasians.
许多研究报道了 X 射线修复交叉互补组 1（XRCC1）Arg399Gln、Arg194Trp、Arg280His、-77T>C 和 X 射线修复交叉互补组 3（XRCC3）T241M 多态性与肺癌风险之间的关联，但结果仍存在争议。因此，我们进行了一项荟萃分析，以调查 XRCC1 Arg399Gln（41 项研究中的 14156 例病例和 16667 例对照）、Arg194Trp（23 项研究中的 7426 例病例和 9603 例对照）、Arg280His（16 项研究中的 6211 例病例和 6763 例对照）、-77T>C（5 项研究中的 2487 例病例和 2576 例对照）和 XRCC3 T241M（19 项研究中的 8560 例病例和 11557 例对照）在不同遗传模型中的关联。我们发现-77T>C 多态性与肺癌风险增加相关（显性模型：比值比 [OR] = 1.45，95%置信区间 [CI] = 1.27-1.66，隐性模型：OR = 1.73，95% CI = 1.14-2.62，加性模型：OR = 1.91，95% CI = 1.24-1.94），当所有合格研究都纳入荟萃分析时。在分层和敏感分析中，总体分析显示肺癌风险显著降低（显性模型：OR = 0.83，95% CI = 0.78-0.89；隐性模型：OR = 0.90，95% CI = 0.81-1.00；加性模型：OR = 0.82，95% CI = 0.74-0.92），白种人（显性模型：OR = 0.82，95% CI = 0.76-0.87；隐性模型：OR = 0.89，95% CI = 0.80-0.99；加性模型：OR = 0.81，95% CI = 0.73-0.91）和基于医院的对照（显性模型：OR = 0.81，95% CI = 0.76-0.88；隐性模型：OR = 0.89，95% CI = 0.79-1.00；加性模型：OR = 0.80，95% CI = 0.71-0.90）与 XRCC3 T241M 相关。总之，这项荟萃分析表明，XRCC1-77T>C 显示出肺癌风险增加，而 XRCC3 T241M 多态性与肺癌风险降低相关，尤其是在白种人中。
