X 射线修复交叉互补基因 1、2、3 多态性与甲状腺癌易感性的 Meta 分析。
A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer.
机构信息
Department of Otolaryngology, Head and Neck Surgery, Otorhinolaryngology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Asian Pac J Cancer Prev. 2021 Jul 1;22(7):2221-2236. doi: 10.31557/APJCP.2021.22.7.2221.
BACKGROUND
We conducted a comprehensive meta-analysis to explore the association of polymorphisms at XRCC1, XRCC2 and XRCC3 genes with susceptibility to thyroid cancer (TC).
METHODS
We searched PubMed, EMBASE, Web of Science, and CNKI for relevant available studies. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of the associations.
RESULTS
A total of 67 studies including 17 studies with 6,806 cases and 5,229 controls on XRCC1 Arg399Gln, 13 studies with 3,234 cases and 4,807 controls on XRCC1 Arg280His, 13 studies with 2,956 cases and 3,860 controls on XRCC1 Arg194Trp, five studies with 1,287 cases and 1,422 controls on XRCC2 Arg188His, 13 studies with 2,488 cases and 3,586 controls on XRCC3 Thr241Met, and six studies with 1,828 cases and 2,060 controls on XRCC3 IVS5-14 polymorphism were selected. Polled data revealed that the XRCC1 Arg399Gln, Arg280His, Arg194Trp, XRCC2 Arg188His and XRCC3 Thr241Met and IVS5-14 polymorphisms were not significantly associated with an increased risk of TC. Stratified analyses by ethnicity showed that the XRCC1 Arg399Gln polymorphism was associated with TC risk in Caucasians, but not in Asians.
CONCLUSIONS
Our meta-analysis indicated that the XRCC1 Arg399Gln, Arg280His, Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met and IVS5-14 polymorphisms were not associated with risk of TC in the global population. Further well-designed investigations with large sample sizes are required to confirm our results.
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背景
我们进行了一项综合荟萃分析，以探讨 XRCC1、XRCC2 和 XRCC3 基因的多态性与甲状腺癌（TC）易感性之间的关联。
方法
我们检索了 PubMed、EMBASE、Web of Science 和 CNKI 中相关的可用研究。使用合并的优势比（OR）及其 95%置信区间（CI）来评估关联的强度。
结果
共纳入 67 项研究，其中 17 项研究涉及 XRCC1 Arg399Gln 多态性，包括 6806 例病例和 5229 例对照，13 项研究涉及 XRCC1 Arg280His 多态性，包括 3234 例病例和 4807 例对照，13 项研究涉及 XRCC1 Arg194Trp 多态性，包括 2956 例病例和 3860 例对照，5 项研究涉及 XRCC2 Arg188His 多态性，包括 1287 例病例和 1422 例对照，13 项研究涉及 XRCC3 Thr241Met 多态性，包括 2488 例病例和 3586 例对照，6 项研究涉及 XRCC3 IVS5-14 多态性，包括 1828 例病例和 2060 例对照。汇总数据显示，XRCC1 Arg399Gln、Arg280His、Arg194Trp、XRCC2 Arg188His 和 XRCC3 Thr241Met 及 IVS5-14 多态性与 TC 风险增加无关。按种族进行的分层分析显示，XRCC1 Arg399Gln 多态性与白种人 TC 风险相关，但与亚洲人无关。
结论
本荟萃分析表明，XRCC1 Arg399Gln、Arg280His、Arg194Trp、XRCC2 Arg188His、XRCC3 Thr241Met 和 IVS5-14 多态性与全球人群 TC 风险无关。需要进一步进行设计良好、样本量大的研究来证实我们的结果。
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