Ji Qing-Shan, Qi Bing, Liu Lian, Lao Wei, Yang Zhi-Hao, Wang Gui-Fang, Yu Guo-Cheng, Zhong Jing-Xiang
Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
Int J Ophthalmol. 2013 Aug 18;6(4):448-51. doi: 10.3980/j.issn.2222-3959.2013.04.07. eCollection 2013.
To observe effects of trabeculectomy with amniotic membrane transplantation (AMT) in controlling postoperative intraocular pressure (IOP) in patients with medically uncontrolled glaucoma.
This study included adult patients with requiring bilateral glaucoma surgery. Each patient underwent trabeculectomy (Non-AMT group) in one eye and with AMT (AMT group) in the other eye according to randomized principle. Success was defined as intraocular pressure (IOP)<21mmHg without any anti-glaucoma medications at 24 months follow-up. The two groups were compared in terms of IOP, complications and success rate.
Thirty-four eyes of 17 patients were investigated in this study. There was no statistically signifcant difference in pre-operative IOP between the two groups. The mean IOP was lower in AMT group compared with Non-AMT group on follow up months 12, 18, and 24.Postoperative complications were more frequent in Non-AMT group (35.3%, 6/17) compared with AMT group (5.9%, 1/17). The success rate of surgery was 88.2% (15/17) in Non-AMT group and 100% (17/17) in AMT group.
Trabeculectomy with AMT is an effective procedure to reduce IOP and complications, thereby improving surgical success rates.
观察小梁切除术联合羊膜移植术（AMT）对药物治疗无法控制的青光眼患者术后眼压（IOP）的控制效果。
本研究纳入需要进行双侧青光眼手术的成年患者。根据随机原则，每位患者一只眼行小梁切除术（非AMT组），另一只眼行小梁切除术联合AMT（AMT组）。成功定义为在24个月随访时眼压（IOP）<21mmHg且未使用任何抗青光眼药物。比较两组的眼压、并发症及成功率。
本研究共调查了17例患者的34只眼。两组术前眼压无统计学显著差异。在随访的第12、18和24个月，AMT组的平均眼压低于非AMT组。非AMT组术后并发症发生率（35.3%，6/17）高于AMT组（5.9%，1/17）。非AMT组手术成功率为88.2%（15/17），AMT组为100%（17/17）。
小梁切除术联合AMT是降低眼压和并发症、提高手术成功率的有效方法。
