Kitajima Kazuhiro, Murphy Robert C, Nathan Mark A, Sugimura Kazuro
Department of Radiology, Kobe University School of Medicine, Kobe, Japan.
Int J Urol. 2014 Jan;21(1):12-23. doi: 10.1111/iju.12250. Epub 2013 Sep 1.
Prostate cancer is the most common non-cutaneous malignancy among men in the Western world, and continues to be a major health problem. Imaging has recently become more important in the clinical management of prostate cancer patients, including diagnosis, staging, choice of optimal treatment strategy, treatment follow up and restaging. Positron emission tomography, a functional and molecular imaging technique, has opened a new field in clinical oncological imaging. The most common positron emission tomography radiotracer, 18F-fluorodeoxyglucose, has been limited in imaging of prostate cancer. Recently, however, other positron emission tomography tracers, such as 11C-acetate and 11C- or (18) F-choline, have shown promising results. In the present review article, we overview the potential and current use of positron emission tomography or positron emission tomography/computed tomography imaging employing the four most commonly used positron emission tomography radiotracers, 18F-fluorodeoxyglucose, 11C-acetate and 11C- or 18F-choline, for imaging evaluation of prostate cancer.
前列腺癌是西方世界男性中最常见的非皮肤恶性肿瘤，并且仍然是一个主要的健康问题。影像学最近在前列腺癌患者的临床管理中变得更加重要，包括诊断、分期、最佳治疗策略的选择、治疗随访和重新分期。正电子发射断层扫描是一种功能和分子成像技术，在临床肿瘤学成像领域开辟了一个新领域。最常见的正电子发射断层扫描放射性示踪剂18F-氟脱氧葡萄糖在前列腺癌成像中存在局限性。然而，最近其他正电子发射断层扫描示踪剂，如11C-醋酸盐和11C-或18F-胆碱，已显示出有前景的结果。在本综述文章中，我们概述了使用四种最常用的正电子发射断层扫描放射性示踪剂，即18F-氟脱氧葡萄糖、11C-醋酸盐和11C-或18F-胆碱的正电子发射断层扫描或正电子发射断层扫描/计算机断层扫描成像在前列腺癌成像评估中的潜力和当前应用情况。
