Wang Wen-Jing, Tao Zhen, Gu Wei, Sun Li-Hua
Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Asian Pac J Cancer Prev. 2013;14(7):4369-71. doi: 10.7314/apjcp.2013.14.7.4369.
To evaluate the association of a diagnosis of lung cancer and combined detection of serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), neuron specific enolase (NSE) as well as the cytokeratin 19 fragment (CYFRA21-1).
Serum CEA, CA19-9, NSE and CYFRA21-1 were assessed in 150 patients with lung cancer, 100 patients with benign lung disease and 100 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of lung cancer were analyzed.
Serum CEA, CA19-9, NSE and CYFRA21-1 in patients with lung cancer were significantly higher than those with benign lung disease and normal controls (p<0.01). It is suggested that these four tumor markers combined together could produce a positive detection rate of 90.2%, significantly higher than that of any single test.
Combination detection of CEA, CA19-9, NSE and CYFRA21-1 could significantly improve the sensitivity and specificity in diagnosis of lung cancer, and could be important in early detection.
评估肺癌诊断与血清癌胚抗原（CEA）、糖类抗原19-9（CA19-9）、神经元特异性烯醇化酶（NSE）以及细胞角蛋白19片段（CYFRA21-1）联合检测之间的关联。
对150例肺癌患者、100例良性肺病患者和100例正常对照者的血清CEA、CA19-9、NSE和CYFRA21-1进行检测，比较各组表达差异，并分析这些肿瘤标志物在肺癌诊断中的联合作用。
肺癌患者血清CEA、CA19-9、NSE和CYFRA21-1显著高于良性肺病患者和正常对照者（p<0.01）。提示这四种肿瘤标志物联合检测的阳性检出率可达90.2%，显著高于任何单项检测。
CEA、CA19-9、NSE和CYFRA21-1联合检测可显著提高肺癌诊断的敏感性和特异性，对早期发现具有重要意义。
