Sigari Naseh, Mohsenpour Behzad, Nikkhoo Bahram, Ghaderi Bayazid, Afkhamzadeh Abdolrahim, Azadi Namam-Ali, Fathi Fardin, Abdi Mohammad
Department of Internal Medicine, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Infectious Diseases, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Clin Lab. 2014;60(1):23-7. doi: 10.7754/clin.lab.2013.121003.
Finding a suitable marker with high sensitivity and specificity for early diagnosis of cancer is very desirable. This study was aimed to determine the diagnostic value of serum CYFRA21-1, carcinoembryonic antigen (CEA), and neuron-specific enolase (NSE) for screening of lung cancer patients in western Iran.
This descriptive analytical case-control study was performed on 30 subjects with malignant and 81 with benign lung cancer. Serum levels of CYFRA21-1, CEA, and NSE were determined.
The concentration of serum tumor markers was significantly higher in the malignant group than in the benign subjects. The highest sensitivity was obtained by measurement of serum NSE (73%). The highest specificity was obtained by measurement of serum CYFRA21-1 (95%).
Our results demonstrate the usefulness of measuring CYFRA21-1 and NSE together for early screening of lung cancer in western Iran.
找到一种对癌症早期诊断具有高灵敏度和特异性的合适标志物是非常理想的。本研究旨在确定血清细胞角蛋白片段21-1（CYFRA21-1）、癌胚抗原（CEA）和神经元特异性烯醇化酶（NSE）对伊朗西部肺癌患者筛查的诊断价值。
本描述性分析病例对照研究对30例恶性肺癌患者和81例良性肺癌患者进行。测定血清CYFRA21-1、CEA和NSE水平。
恶性组血清肿瘤标志物浓度显著高于良性组。血清NSE检测的灵敏度最高（73%）。血清CYFRA21-1检测的特异性最高（95%）。
我们的结果表明，联合检测CYFRA21-1和NSE对伊朗西部肺癌的早期筛查有用。
