Department of Biomedical and Specialist Surgical Sciences .
Gynecol Endocrinol. 2013 Dec;29(12):1063-6. doi: 10.3109/09513590.2013.831829. Epub 2013 Aug 30.
The aim of the present study was to investigate whether accumulation of central fat is correlated with systemic oxidative stress (OxS) in non-obese apparently healthy postmenopausal women. Serum parameters of OxS (hydroperoxides and non-enzymatic antioxidants) along with body fat distribution, as assessed by dual-energy-X-ray absorptiometry (DXA), were evaluated in 134 non-obese postmenopausal women. Multiple regression analysis showed that central (trunk) fat significantly correlated with both markers of OxS independently of confounding factors (i.e. BMI, smoking, age, hypertension, legs and arms fat mass). In specific, the standardized regression coefficient was positive for hydroperoxides (β = 0.324, p < 0.05) and negative for antioxidants (β = -0.495, p < 0.01) level. In conclusion, the current data showed that the increase in central fat is an independent predictor of OxS condition among non-obese women in postmenopausal status. The possible pro-oxidant effects of the excess in central adiposity might be more harmful among post- than among pre-menopausal women, due to the postulated ability of E2 to contrast oxidative challenge and the related diseases.
本研究旨在探讨非肥胖、貌似健康的绝经后妇女体内中心性脂肪堆积与全身性氧化应激（OxS）之间是否存在相关性。通过双能 X 射线吸收仪（DXA）评估了 134 名非肥胖绝经后妇女的 OxS 血清参数（羟自由基和非酶抗氧化剂）以及体脂分布。多元回归分析显示，中心性（躯干）脂肪与 OxS 的两种标志物均独立于混杂因素（即 BMI、吸烟、年龄、高血压、四肢脂肪量）显著相关。具体而言，羟自由基的标准化回归系数为正（β=0.324，p<0.05），抗氧化剂的标准化回归系数为负（β=-0.495，p<0.01）。总之，目前的数据表明，非肥胖绝经后妇女中心性脂肪增加是 OxS 状况的独立预测因子。由于假定 E2 具有对抗氧化应激和相关疾病的能力，因此与绝经前妇女相比，中心性肥胖过多可能对绝经后妇女造成更大的促氧化作用。
