Department of Biochemistry and Molecular Biology, University of Ferrara, via Luigi Borsari 46, Ferrara, Italy.
Maturitas. 2013 May;75(1):62-6. doi: 10.1016/j.maturitas.2013.01.014. Epub 2013 Feb 12.
The present study aimed to investigate any associations between parameters of body fat mass distribution and levels of serum uric acid (sUA), a well-documented cardiovascular risk factor, among non-obese women ranging from pre- to post-menopausal status.
In this cross-sectional population-based study we assessed body fat distribution by dual-energy-X-ray absorptiometry (DXA), and sUA levels in 101 pre- and 134 post-menopausal non-obese apparently healthy women.
Multivariate stepwise regression analysis revealed that sUA was independently associated to the indicators of overall fatness, i.e. body mass index (β=0.339, p<0.001) and DXA-assessed total and percentage body fat (β=0.366, p<0.001 and β=0.412, p<0.001, respectively), only among post-menopausal women. Within this sample subset, trunk (i.e. central) fat mass emerged as a strong predictor of sUA (β=0.408, p<0.001), after taking the potential confounders (including body mass index) into account.
Central fat accumulation was found to be independently associated with higher sUA levels among non-obese women in post- but not among those in pre-menopause.
本研究旨在探讨非肥胖绝经前和绝经后女性体脂分布参数与血清尿酸（sUA）水平之间的关系，sUA 是一种已被充分证实的心血管危险因素。
在这项基于人群的横断面研究中，我们使用双能 X 射线吸收法（DXA）评估体脂分布，检测 101 名绝经前和 134 名绝经后非肥胖、貌似健康的女性的 sUA 水平。
多元逐步回归分析显示，sUA 与整体肥胖指标（即 BMI，β=0.339，p<0.001）和 DXA 评估的总脂肪量和脂肪百分比（β=0.366，p<0.001 和β=0.412，p<0.001）独立相关，仅在绝经后女性中如此。在这个样本子集中，在考虑到潜在的混杂因素（包括 BMI）后，躯干部（即中心）脂肪量是 sUA 的一个强有力的预测因素（β=0.408，p<0.001）。
在非肥胖绝经后女性中，中心性脂肪堆积与较高的 sUA 水平独立相关，但在绝经前女性中则不然。
