Huang Zhiquan, Zhuo Ying, Shen Zhuojian, Wang Youyuan, Wang Lili, Li Haigang, Chen Ju, Chen Weiliang
Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Key Laboratory of malignant tumor gene regulation and target therapy of Guangdong Higher Education Institutes, Sun Yat-sen University, Guangzhou, Guangdong, China.
J Oral Pathol Med. 2014 Mar;43(3):191-8. doi: 10.1111/jop.12109. Epub 2013 Aug 31.
The neurofilament light polypeptide (NEFL) gene located on chromosome 8q21 is associated with the cancer of several organs and is regarded as a potential tumor suppressor gene. However, the role of the NEFL protein has not yet been studied in cancer cells. Although evidence suggests that there is a correlation between NEFL expression and cancer, studies regarding the role of the NEFL protein have been mostly limited to neurological diseases, such as Charcot-Marie-Tooth's disease (CMT). Most of these studies have not explored the role of NEFL in cancer cell apoptosis and/or invasion. In this study, NEFL expression was manipulated, and apoptosis and invasion were compared in head and neck squamous cell carcinoma cell lines. The results show that the expression of NEFL induces cancer cell apoptosis and inhibits invasion in these cell lines, suggesting that NEFL may play a role in cancer cell apoptosis and invasion.
位于8号染色体q21的神经丝轻链多肽（NEFL）基因与多个器官的癌症相关，被视为一种潜在的肿瘤抑制基因。然而，NEFL蛋白在癌细胞中的作用尚未得到研究。尽管有证据表明NEFL表达与癌症之间存在关联，但关于NEFL蛋白作用的研究大多局限于神经疾病，如夏科-马里-图斯病（CMT）。这些研究大多未探讨NEFL在癌细胞凋亡和/或侵袭中的作用。在本研究中，对NEFL表达进行了调控，并在头颈部鳞状细胞癌细胞系中比较了细胞凋亡和侵袭情况。结果表明，NEFL的表达诱导了这些细胞系中的癌细胞凋亡并抑制了侵袭，提示NEFL可能在癌细胞凋亡和侵袭中发挥作用。
