De Souza B, Brunetti A, Fulham M J, Brooks R A, DeMichele D, Cook P, Nieman L, Doppman J L, Oldfield E H, Di Chiro G
Neuroimaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Radiology. 1990 Oct;177(1):39-44. doi: 10.1148/radiology.177.1.2399336.
Twenty cases of surgically verified pituitary microadenoma (17 with Cushing disease and three with acromegaly) were studied with positron emission tomography (PET) with use of fluorine-18-2-fluorodeoxyglucose (FDG). The diagnostic results were compared with those of other modalities, namely, computed tomography (CT), magnetic resonance (MR) imaging, and, in the cases of Cushing disease, simultaneous bilateral inferior petrosal sinus sampling (SIPS). The PET results showed 12 positive readings and one questionable reading, compared with seven positive readings and one questionable reading for CT (18 cases studied) and 13 positive and two questionable MR imaging readings. PET complemented MR imaging, in the sense that five of the positive PET readings were negative or questionable at MR imaging. PET studies of 20 healthy control subjects showed no false-positive cases, whereas other studies of healthy subjects with contrast material-enhanced CT and MR imaging have yielded, respectively, 20% and 15% positive readings, with findings suggestive of silent or occult adenomas.
对20例经手术证实的垂体微腺瘤患者（17例库欣病患者和3例肢端肥大症患者）使用氟-18-2-氟脱氧葡萄糖（FDG）进行正电子发射断层扫描（PET）研究。将诊断结果与其他检查方式的结果进行比较，其他检查方式包括计算机断层扫描（CT）、磁共振（MR）成像，对于库欣病患者，还与同步双侧岩下窦采血（SIPS）的结果进行比较。PET结果显示12例阳性读数和1例可疑读数，相比之下，CT（共研究18例）有7例阳性读数和1例可疑读数，MR成像有13例阳性读数和2例可疑读数。PET对MR成像起到了补充作用，因为PET的5例阳性读数在MR成像时为阴性或可疑。对20名健康对照者进行的PET研究未显示假阳性病例，而其他针对健康受试者的增强CT和MR成像研究分别产生了20%和15%的阳性读数，结果提示存在无症状或隐匿性腺瘤。
