Kerns Sarah L, de Ruysscher Dirk, Andreassen Christian N, Azria David, Barnett Gillian C, Chang-Claude Jenny, Davidson Susan, Deasy Joseph O, Dunning Alison M, Ostrer Harry, Rosenstein Barry S, West Catharine M L, Bentzen Søren M
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, USA; Department of Pathology, Albert Einstein College of Medicine, New York, USA; Department of Genetics, Albert Einstein College of Medicine, New York, USA.
Department of Radiation Oncology, University Hospitals Leuven/KU Leuven, Belgium.
Radiother Oncol. 2014 Jan;110(1):182-8. doi: 10.1016/j.radonc.2013.07.011. Epub 2013 Aug 27.
Despite publication of numerous radiogenomics studies to date, positive single nucleotide polymorphism (SNP) associations have rarely been reproduced in independent validation studies. A major reason for these inconsistencies is a high number of false positive findings because no adjustments were made for multiple comparisons. It is also possible that some validation studies were false negatives due to methodological shortcomings or a failure to reproduce relevant details of the original study. Transparent reporting is needed to ensure these flaws do not hamper progress in radiogenomics. In response to the need for improving the quality of research in the area, the Radiogenomics Consortium produced an 18-item checklist for reporting radiogenomics studies. It is recognised that not all studies will have recorded all of the information included in the checklist. However, authors should report on all checklist items and acknowledge any missing information. Use of STROGAR guidelines will advance the field of radiogenomics by increasing the transparency and completeness of reporting.
尽管迄今为止已发表了大量的放射基因组学研究，但阳性单核苷酸多态性（SNP）关联在独立验证研究中很少被重现。这些不一致的一个主要原因是存在大量假阳性结果，因为未对多重比较进行校正。也有可能一些验证研究由于方法学缺陷或未能重现原始研究的相关细节而成为假阴性。需要透明的报告来确保这些缺陷不会阻碍放射基因组学的进展。为响应提高该领域研究质量的需求，放射基因组学联盟制定了一份包含18项条目的放射基因组学研究报告清单。人们认识到并非所有研究都会记录清单中包含的所有信息。然而，作者应报告清单上的所有项目，并说明任何缺失的信息。使用STROGAR指南将通过提高报告的透明度和完整性来推动放射基因组学领域的发展。
