The Massachusetts General Hospital, USA.
University of Pittsburgh Medical Center, USA.
J Affect Disord. 2013 Nov;151(2):722-727. doi: 10.1016/j.jad.2013.07.031. Epub 2013 Aug 16.
Individuals with bipolar disorder lead a sedentary lifestyle associated with worse course of illness and recurrence of symptoms. Identifying potentially modifiable predictors of exercise frequency could lead to interventions with powerful consequences on the course of illness and overall health.
The present study examines baseline reports of exercise frequency of bipolar patients in a multi-site comparative effectiveness study of a second generation antipsychotic (quetiapine) versus a classic mood stabilizer (lithium). Demographics, quality of life, functioning, and mood symptoms were assessed.
Approximately 40% of participants reported not exercising regularly (at least once per week). Less frequent weekly exercise was associated with higher BMI, more time depressed, more depressive symptoms, and lower quality of life and functioning. In contrast, more frequent exercise was associated with experiencing more mania in the past year and more current manic symptoms.
Exercise frequency was measured by self-report and details of the exercise were not collected. Analyses rely on baseline data, allowing only for association analyses. Directionality and predictive validity cannot be determined. Data were collected in the context of a clinical trial and thus, it is possible that the generalizability of the findings could be limited.
There appears to be a mood-specific relationship between exercise frequency and polarity such that depression is associated with less exercise and mania with more exercise in individuals with bipolar disorder. This suggests that increasing or decreasing exercise could be a targeted intervention for patients with depressive or mood elevation symptoms, respectively.
双相情感障碍患者的生活方式往往久坐不动，这与疾病进程恶化和症状复发有关。识别出可能可以改变的运动频率预测因素，可能会导致针对疾病进程和整体健康产生重大影响的干预措施。
本研究检查了在第二代抗精神病药（喹硫平）与经典心境稳定剂（锂）的多中心对照效能研究中，双相情感障碍患者的基线运动频率报告。评估了人口统计学、生活质量、功能和情绪症状。
约 40%的参与者报告没有定期锻炼（每周至少一次）。每周运动频率较低与较高的 BMI、抑郁时间较长、抑郁症状较多以及生活质量和功能较低有关。相比之下，更频繁的运动与过去一年中经历更多的躁狂和当前的躁狂症状有关。
运动频率是通过自我报告测量的，没有收集运动的详细信息。分析依赖于基线数据，仅允许进行关联分析。无法确定方向性和预测有效性。数据是在临床试验的背景下收集的，因此，研究结果的普遍性可能受到限制。
在双相情感障碍患者中，运动频率与极性之间似乎存在一种特定于情绪的关系，即抑郁与运动较少有关，而躁狂与运动较多有关。这表明，对于有抑郁或情绪升高症状的患者，增加或减少运动可能是一种有针对性的干预措施。
