Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Melbourne, Victoria, Australia.
Womens Health Issues. 2013 Sep-Oct;23(5):e301-7. doi: 10.1016/j.whi.2013.07.001.
This paper examines the factors associated with depressive symptoms during the perimenopausal transition, to increase the understanding about the etiology of perimenopausal depression.
Seventy-six peri- and early postmenopausal women with or without current depressive symptoms were recruited (mean, 49.5 years; standard deviation, 4.3). Participants completed a series of questionnaires relating to depression (Beck Depression Inventory-II), perimenopausal symptoms (Greene Climacteric Scale), social support, life events, history of mood disorders, exercise regime, and questions regarding lifestyle and well-being.
Univariate relationships between predictors and depression scores were assessed. All significant variables at this level (history of depression, history of premenstrual syndrome, recent negative life events, aerobic exercise, social support, and somatic symptoms) were then analyzed via multiple regression. The presence of recent negative life events, a history of depression, and severity of somatic symptoms of perimenopause were all found to predict unique variance in depression scores. There was also a trend toward a protective role of aerobic exercise.
This study confirmed the role of negative life events, previous depression history, and somatic complaints in the development of depressive symptoms during perimenopause. Further exploration of this relationship is warranted.
本研究旨在探讨围绝经期过渡期间与抑郁症状相关的因素，以增加对围绝经期抑郁病因的理解。
本研究共招募了 76 名围绝经期和绝经早期有或无当前抑郁症状的女性（平均年龄 49.5 岁，标准差 4.3）。参与者完成了一系列与抑郁相关的问卷（贝克抑郁量表第二版）、围绝经期症状（格林绝经量表）、社会支持、生活事件、心境障碍史、运动方案以及关于生活方式和幸福感的问题。
在单变量分析中评估了预测因子与抑郁评分之间的关系。在这一水平上所有显著的变量（抑郁史、经前综合征史、近期负性生活事件、有氧运动、社会支持和躯体症状）随后通过多元回归进行分析。近期负性生活事件的存在、抑郁史和围绝经期躯体症状的严重程度均被发现可预测抑郁评分的独特差异。有氧运动也有一定的保护作用趋势。
本研究证实了消极生活事件、既往抑郁史和躯体主诉在围绝经期发展为抑郁症状中的作用。需要进一步探讨这种关系。
