State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Fitoterapia. 2013 Dec;91:95-99. doi: 10.1016/j.fitote.2013.08.015. Epub 2013 Aug 30.
Five new labdane diterpenes (1-5), serralabdanes A-E, were isolated from the whole plant of Chloranthus serratus. Their structures were elucidated by spectroscopic methods, and the absolute configuration of the 12,13-diol moiety in serralabdane C (3) was determined by observing the induced circular dichroism (ICD) after addition of dimolybdenum teracetate in DMSO solution. Serralabdanes A-E (1-5) showed inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
从金粟兰科金粟兰属植物全缘金粟兰中分离得到 5 个新的贝壳杉烷二萜化合物（1-5），分别命名为 serralabdanes A-E。通过波谱方法解析了它们的结构，并通过在 DMSO 溶液中二钼酸二叔丁酯加入后观察诱导圆二色性（ICD）确定了 serralabdane C（3）中 12,13-二醇部分的绝对构型。Serralabdanes A-E（1-5）对 RAW264.7 细胞中脂多糖诱导的一氧化氮生成具有抑制作用。
